J Pathol Transl Med.  2020 Sep;54(5):432-434. 10.4132/jptm.2020.07.01.

Breast implant–associated anaplastic large cell lymphoma: the first South Korean case

• Lee J
• Cho H
• Yoon DH
• Kim EK
• Gong G
• Suh C
• Huh Jr

• KMID: 2506277
• DOI: http://doi.org/10.4132/jptm.2020.07.01

Figure

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  Fig. 1. Imaging studies. (A) Ultrasonography of the right breast shows suspected inner capsule discontinuity due to fluid collection, suspicious for rupture. (B) Magnetic resonance imaging of the breasts. Fat-suppressed T2-weighted axial image and dynamic contrast-enhanced T1-weighted axial image were processed. Fluid collection was identified at the inner side of the right breast capsule.

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  Fig. 2. (A) Large lymphocytes with binucleation and horseshoe-like nuclear indentation are visible. Tumor cells are admixed with mature, small lymphocytes for size comparison (SurePath Papanicolaou stain, Becton, Dickinson and Company, Franklin Lakes, NJ, USA). (B) Large atypical cells positive for CD30 are admixed with mature lymphocytes. (C) Large neoplastic cells with membranous, Golgi staining pattern of CD30 immunolabeling.

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  Fig. 3. The capsule removed from the right breast. (A) The capsule appeared irregularly thickened without definite “tumor” masses though with irregular, fibrin-like deposits in multiple foci. (B) Microscopically, atypical large lymphocytes with indented, kidney-shaped nuclei (arrows) had infiltrated the fibrinous material on the luminal side of the capsule. (C) The same cells show diffuse CD30 immunopositivity. (D) Foreign body–type giant cells were gathered around the deep surface of the capsule.

Reference

References

1. Di Napoli A, Pepe G, Giarnieri E, et al. Cytological diagnostic features of late breast implant seromas: from reactive to anaplastic large cell lymphoma. PLoS One. 2017; 12:e0181097.

2. Quesada AE, Medeiros LJ, Clemens MW, Ferrufino-Schmidt MC, Pina-Oviedo S, Miranda RN. Breast implant-associated anaplastic large cell lymphoma: a review. Mod Pathol. 2019; 32:166–88.