Obstet Gynecol Sci.  2020 Jul;63(4):490-496. 10.5468/ogs.19242.

Is placental KISS-1 expression associated with first trimester abortion spontaneous?

• Colak E
• Ozcimen EE
• Erinanç OH
• Tohma YA
• Ceran MU

• KMID: 2505039
• DOI: http://doi.org/10.5468/ogs.19242

Abstract

Objective
Several studies have examined biological markers during the first trimester to predict the maintenance of a healthy pregnancy. One such marker is kisspeptin, which is encoded by the KISS-1 gene. We aimed to determine whether firsttrimester pregnancy losses were associated with levels of placental KISS-1 expression.
Methods
This prospective case control study was conducted at a tertiary center. The study group included 27 and 24 patients who underwent dilation and curettage at <10 weeks of gestation, due to first trimester spontaneous pregnancy loss and for elective termination (control), respectively. Placental and decidual tissues from all patients were sectioned and immunohistochemically analyzed for kisspeptin.
Results
Age, gravida status, parity number, gestational week, and number of previous abortions did not significantly differ between the groups. KISS-1 expression levels were significantly lower in the group with spontaneous abortion compared with the group with elective termination. The median staining intensity of KISS-1 expression in the elective and spontaneous termination groups were 3 (strong) and 2 (moderate), respectively (P=0.004). KISS-1 expression levels were significantly lower among patients with previous abortions in the elective termination group (P=0.002).
Conclusion
KISS-1 expression levels were found to be significantly reduced in patients with spontaneous pregnancy loss; KISS-1 plays an important role in the implantation and continuation of pregnancy.

Keyword

Genes, tumor suppressor; Abortion, spontaneous; Pregnancy, unwanted; Placenta

Figure

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  Fig. 1. Weak (+) staining intensity.

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  Fig. 2. Strong (+++) intensity of staining.

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  Fig. 3. Sensitivity and specificity for KISS-1.

Reference

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