Allergy Asthma Respir Dis.  2020 Jul;8(3):161-164. 10.4168/aard.2020.8.3.161.

Three cases of oral immunotherapy for IgE-mediated egg allergy

  • 1Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
  • 2Department of Pediatrics, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea
  • 3Department of Pediatrics, Kosin University Gospel Hospital, Kosin University School of Medicine, Busan, Korea
  • 4Oz Pediatric Clinic, Yongin, Korea
  • 5Department of Pediatrics, Hallym University Dongtan Sacred Heart Hospital, Hallym University School of Medicine, Hwasung, Korea
  • 6Department of Pediatrics, Hallym University Hangang Sacred Heart Hospital, Hallym University School of Medicine, Seoul, Korea
  • 7Environmental Health Center for Atopic Diseases, Samsung Medical Center, Seoul, Korea


Food allergy is an immune-mediated adverse reaction that occurs mainly by food ingestion. Some children with food allergies manifest fatal symptoms like anaphylaxis. Oral immunotherapy (OIT) may offer an effective therapeutic modality for persistent and severe forms of food allergies. We report our experience with OIT in 3 patients with IgE-mediated hen’s egg allergy. Our treatment strategy consists of 1–3 days of initial escalation, 47 to 65 weeks of build-up phase, and 1 year of maintenance phase. Lactobacillus plantarum CJLP133, 1×1010 colony-forming unit/day was taken during OIT. As a result, 1 patient achieved successful desensitization, and 1 patient reached maintenance therapy, but did not obtain desensitization. In addition, 1 patient withdrew from treatment due to anxiety symptoms. Despite the limited number of patients, we experienced and herein presented 3 cases of OIT in egg allergy. More trials of OIT need to be performed as a treatment option in Korean children with food allergies.


Food allergy; Anaphylaxis; Oral immunotherapy
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