Cancer Res Treat.  2020 Jul;52(3):671-679. 10.4143/crt.2019.387.

Comparison of the Distribution Pattern of 21-Gene Recurrence Score between Mucinous Breast Cancer and Infiltrating Ductal Carcinoma in Chinese Population: A Retrospective Single-Center Study

• Wu J
• Ding S
• Lin L
• Fei X
• Lin C
• Andriani L
• Goh C
• Huang J
• Hong J
• Gao W
• Zhu S
• Wang H
• Huang O
• Chen X
• He J
• Li Y
• Shen K
• Chen W
• Zhu L

• KMID: 2504449
• DOI: http://doi.org/10.4143/crt.2019.387

Abstract

Purpose
This retrospective study aimed to evaluate the distribution pattern and prognostic value of 21-gene recurrence score (RS) in Chinese patients with mucinous breast cancer (MC) and compared with infiltrating ductal carcinoma (IDC).
Materials and Methods
Patients diagnosed with MC or IDC from January 2010 to January 2017 were retrospectively recruited. Reverse transcriptase–polymerase chain reaction assay of 21 genes was conducted to calculate the RS. Univariate and multivariate analyses were performed to assess the association between RS and clinicopathological factors. Survival outcomes including disease-free survival (DFS) and overall survival (OS) were estimated by Kaplan-Meier method and compared by log-rank test.
Results
The MC cohort included 128 patients and the IDC cohort included 707 patients. The proportions of patients with a low (RS < 18), intermediate (18-30), or high risk (RS > 30) were 32.0%, 48.4%, and 19.5% in MC cohort, and 26.9%, 46.8% and 26.3% in IDC cohort. The distribution of RS varied significantly according to different Ki-67 index and molecular subtype in both cohorts. Moreover, the receipt of chemotherapy was associated with RS in both cohorts. Among patients with MC, tumor stage was related to the DFS (p=0.040). No significant differences in DFS and OS were found among MC patients in different RS risk groups (OS, p=0.695; DFS, p=0.926).
Conclusion
RS was significantly related to Ki-67 index and molecular subtypes in MC patients, which is similar in IDC patients. However, RS was not able to predict DFS and OS in patients with MC.

Keyword

Mucinous mammary malignancy; Multigene assay; Prognosis

Figure

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  Fig. 1. Kaplan-Meier survival curves in mucinous breast cancer patients according to different recurrence score risk groups. Disease-free survival (DFS) (A) and overall survival (OS) (B).

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  Fig. 2. Kaplan-Meier survival curves in invasive ductal carcinoma patients according to different recurrence score risk groups. Disease-free survival (DFS) (A) and overall survival (OS) (B).

Reference

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