Korean J Dent Mater.  2020 Jun;47(2):63-70. 10.14815/kjdm.2020.47.2.63.

Sustainability of the antibacterial activity of experimental fluoride varnish mixed with antibacterial agents against Streptococcus mutans

  • 1Department of Dental Hygiene, Wonkwang Health Science University, Iksan, Korea
  • 2Department of Dental Biomaterials and Institute of Biomaterials·Implant, Wonkwang University, Iksan, Korea


This study aimed to assess the sustainability of antibacterial agents mixed with experimental fluoride varnish (EFV) against S. mutans. Five antibacterial agents [Xanthorrhizol (XAN), Bakuchiol (BAK), Bavachalcone (BCC), Isobavachromene (IBC), and Bavachromene (BCM)] were used and incorporated into the EFV to make the final concentration of 10 mM. Then, 5 μL of antibacterial agents mixed with EFV were applied on polyethylene terephthalate film disc (5 mm diameter). The positive and vehicle control were ampicillin and DMSO mixed with EFV, respectively. Each group was stored in distilled water in a 37℃ shaking water bath at 80 rpm for 0 hour, 4 hours, 1 day, 2 days, 3 days, 5 days, 10 days, 20 days and 30 days. The sustainability of the antibacterial activities was evaluated with the inhibition zone by the agar diffusion test. The antibacterial activities of all antibacterial agents were sustained for 30 days. Among them, BCC showed relatively higher antibacterial activities up to 30 days compared to other groups. This study suggests that antibacterial agents including BCC can be used with fluoride varnish to have sustained antibacterial activities.


Sustainability of antibacterial activity; Antibacterial agents; Fluoride varnish; Streptococcus mutans
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