Mycobiology.
2020 Apr;48(2):148-152. 10.1080/12298093.2020.1744955.
Antifungal Susceptibility Tests and the cyp51 Mutant Strains among Clinical Aspergillus fumigatus Isolates from Korean Multicenters
- Affiliations
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- 1Department of Laboratory Medicine, Chonnam National University Medical School, Gwangju, Korea
- 2Department of Parasitology and Tropical Medicine, Chonnam National University Medical School, Gwangju, Korea
- 3Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, South Korea
- 4Department of Laboratory Medicine, The Catholic University of Korea College of Medicine, Seoul, Republic of Korea
- 5Department of Microbiology, Chonnam National University Medical School, Gwangju, Korea
- KMID: 2503920
- DOI: http://doi.org/10.1080/12298093.2020.1744955
Abstract
- We investigated the antifungal susceptibilities and the cyp51 mutant strains among Aspergillus fumigatus clinical isolates obtained from 10 university hospitals in Korea. Of the 84 isolates examined, two itraconazole-resistant isolates were found with no amino acid substitution in the cyp51A/cyp51B genes. However, 19 (23.2%) azole-susceptible isolates harbored amino acid substitutions: Nine isolates harbored one to five mutations in cyp51A with high polymorphism, and 11 isolates exhibited the same Q42L mutation in cyp51B. Overall, a low azole resistance rate and high frequency of cyp51A/cyp51B amino acid substitutions were observed in the azole-susceptible A. fumigatus isolates in Korea.
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