J Biomed Transl Res.  2020 Jun;21(2):50-58. 10.12729/jbtr.2020.21.2.050.

Flavonoid-induced apoptotic cell death in human cancer cells and its mechanisms

• Bhosale PB
• Ha SE
• Vetrivel P
• Kim HH
• Kim JA
• Park KI
• Kim SM
• Kim GS

• KMID: 2503830
• DOI: http://doi.org/10.12729/jbtr.2020.21.2.050

Abstract

Cancer is the second leading cause of death worldwide and currently there are many approaches developing towards cancer treatment. Cancer treatments like chemotherapy and radiation therapy are often painful and have adverse effects. The mechanism of apoptosis is a complex process and it involves different pathways in its mechanism of action. Apoptosis can be caused by signals within the cell such as stress, or by extrinsic signals such as ligands binding to cell surface death receptors. The programmed cell death plays a important role in the several physiological and pathological processes. It plays important role in homeostasis. Flavonoids have gained importance as anticancer agents promoting cytotoxicity and apoptosis in cancer cells. Flavonoids are present in many medicinal plants which are a kind of ubiquitous natural products and essential active ingredients. They have strong biological activities with high efficiency and low toxicity, possessing good preventive and cure effects on different tumor forms. Flavonoids such as Scutellarein, Pectolinarigenin and Naringin have reported to possess significant anti-cancer effects on different cancer cell lines till date. In this review, we provide a summary about the anti-cancer effect of the three flavonoids and its mechanisms of action that can be used in future for understanding their potent anti-tumor properties.

Keyword

apoptosis; flavonoid; scutellarein; pectolinarigenin; naringin