Restor Dent Endod.  2020 May;45(2):e23. 10.5395/rde.2020.45.e23.

Antimicrobial efficacy of QMix on Enterococcus faecalis infected root canals: a systematic review of in vitro studies

• Lim BSH
• Parolia A
• Chia MSY
• Jayaraman J
• Nagendrababu V

• KMID: 2503518
• DOI: http://doi.org/10.5395/rde.2020.45.e23

Abstract

Objectives
This study aimed to summarize the outcome of in vitro studies comparing the antibacterial effectiveness of QMix with other irrigants against Enterococcus faecalis.
Materials and Methods
The research question was developed by using population, intervention, comparison, outcome, and study design framework. The literature search was performed using 3 electronic databases: PubMed, Scopus, and EBSCOhost until October 2019. The additional hand search was performed from the reference list of the eligible studies. The risk of bias of the studies was independently appraised using the revised Cochrane Risk of Bias tool (RoB 2.0).
Results
Fourteen studies were included in this systematic review. The overall risk of bias for the selected studies was moderate. QMix was found to have a higher antimicrobial activity compared to 2% sodium hypochlorite (NaOCl), 17% ethylenediaminetetraacetic acid (EDTA), 2% chlorhexidine (CHX), mixture of tetracycline isonomer, an acid and a detergent (MTAD), 0.2% Cetrimide, SilverSol/H2O2, HYBENX, and grape seed extract (GSE). QMix had higher antibacterial efficacy compared to NaOCl, only when used for a longer time (10 minutes) and with higher volume (above 3 mL).
Conclusions
QMix has higher antibacterial activity than 17% EDTA, 2% CHX, MTAD, 0.2% Cetrimide, SilverSol/H2O2, HYBENX, GSE and NaOCl with lower concentration. To improve the effectiveness, QMix is to use for a longer time and at a higher volume.

Keyword

Chlorhexidine; Enterococcus faecalis; QMix; root canal treatment; systematic review

Figure

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  Figure 1 A flowchart of the literature search process.

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  Figure 2 Risk of bias assessment of included studies.+, low risk of bias; −, high risk of bias.

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