Korean J Health Promot.  2020 Mar;20(1):10-15. 10.15384/kjhp.2020.20.1.10.

Relationships between Subclinical Hypothyroidism and Metabolic Syndrome and Vitamin D Status in Korean Adults: Korea National Health and Nutrition Examination Survey 2013-2015

• Kim YL
• Han AL
• Shin SR

• KMID: 2502693
• DOI: http://doi.org/10.15384/kjhp.2020.20.1.10

Abstract

Background
Many studies have established the association between overt hypothyroidism and metabolic syndrome (MS). However, the relationship between subclinical hypothyroidism (SCH) and MS varies from study to study. This study aimed to investigate associations between SCH and components of MS and vitamin D status in Korean adults.
Methods
Using data from the 6th Korea National Health and Nutrition Examination Survey (2013-2015), chi-squared tests and t-tests were used to explore relationships between thyroid hormones and components of MS and vitamin D status. Multiple regression analysis was undertaken to assess relationships between SCH and components of MS and vitamin D.
Results
Systolic blood pressure and fasting glucose were significantly higher in the euthyroid (EUT) group than in the SCH group, and vitamin D status was significantly lower in the SCH group than EUT. However, in multiple regression analysis, SCH presented no significant association with components of MS or vitamin D status even after adjusting for age, sex, drinking, and smoking.
Conclusions
In Korean adults, there is no significant association between SCH and MS or vitamin D.

Keyword

Subclinical hypothyroidism; Metabolic syndrome; Vitamin D

Reference

1. Park E, Kim J. Gnder and age specific prevalence of metabolic syndrome among Korean adults: analysis of the fifth Korean National Health and Nutrition Examination Survey. J Cardiovasc Nurs. 2015; 30(3):256–66.

2. Pucci E, Chiovato L, Pinchera A. Thyroid and lipid metabolism. Int J Obes Relat Metab Disord. 2000; 24(2):S109–12.

3. Klieverik LP, Janssen SF, van Riel A, Foppen E, Bisschop PH, Serlie MJ, et al. Thyroid hormone modulates glucose production via a sympathetic pathway from the hypothalamic paraventricular nucleus to the liver. Proc Natl Acad Sci U S A. 2009; 106(14):5966–71.

4. Liu C, Scherbaum WA, Schott M, Schinner S. Subclinical hypothyroidism and the prevalence of the metabolic syndrome. Horm Metab Res. 2011; 43(6):417–21.

5. Aldossari K, Al-Ghamdi S, Al-Zahrani J, Al Jammah A, Alanazi B, Al-Briek A, et al. Association between subclinical hypothyroidism and metabolic disorders: a retrospective chart review study in an emerging university hospital. J Clin Lab Anal. 2019; 33(9):e22983.

6. Mehran L, Amouzegar A, Tohidi M, Moayedi M, Azizi F. Serum free thyroxine concentration is associated with metabolic syndrome in euthyroid subjects. Thyroid. 2014; 24(11):1566–74.

7. Lin SY, Wang YY, Liu PH, Lai WA, Sheu WH. Lower serum free thyroxine levels are associated with metabolic syndrome in a Chinese population. Metabolism. 2005; 54(11):1524–8.

8. Lai Y, Wang J, Jiang F, Wang B, Chen Y, Li M, et al. The relationship relationship between serum thyrotropin and components of metabolic syndrome. Endocr J. 2011; 58(1):23–30.

9. Khatiwada S, Sah SK, Kc R, Baral N, Lamsal M. Thyroid dysfunction in metabolic syndrome patients and its relationship with components of metabolic syndrome. Clin Diabetes Endocrinol. 2016; 2:3.

10. Kivity S, Agmon-Levin N, Zisappl M, Shapira Y, Nagy EV, Dankó K, et al. Vitamin D and autoimmune thyroid diseases. Cell Mol Immunol. 2011; 8(3):243–7.

11. Kim D. The role of vitamin D in thyroid diseases. Int J Mol Sci. 2017; 18(9):1949.

12. Kim WG, Kim WB, Woo G, Kim H, Cho Y, Kim TY, et al. Thyroid stimulating hormone reference range and prevalence of thyroid dysfunction in the Korean population: Korea National Health and Nutrition Examination Survey 2013 to 2015. Endocrinol Metab (Seoul). 2017; 32(2):106–14.

13. Park SG, Kim DH, Park JH, Kim EY, Choi M, Kim H, et al. The association between thyroid function and metabolic syndrome in euthyroid Korean male adults: Korean National Health and Nutrition Examination Survey VI. Korean J Fam Pract. 2019; 9(2):154–60.

14. Yoon HJ, Shin HC, Choi JH, Hur YS, Hong SB, Kim YS, et al. The relationship between thyroid hormone and metabolic syndrome in obese euthyroid adults. Korean J Obes. 2008; 17(1):10–9.

15. Park HT, Cho GJ, Ahn KH, Shin JH, Hong SC, Kim T, et al. Thyroid stimulating hormone is associated with metabolic syndrome in euthyroid postmenopausal women. Maturitas. 2009; 62(3):301–5.

16. Nah EH, Lee JG. The relationship between thyroid function and the risk factors of cardiovascular disease at female medical checkups. Korean J Lab Med. 2009; 29(4):286–92.

17. Stone NJ, Bilek S, Rosenbaum S. Recent national cholesterol education program adult treatment panel III update: adjustments and options. Am J Cardiol. 2005; 96(4A):53E–9E.

18. Park HA, Kim SY. Recent advance on vitamin D. J Korean Med Assoc. 2013; 56(4):310–8.

19. Park SB, Choi HC, Joo NS. The relation of thyroid function to components of the metabolic syndrome in Korean men and women. J Korean Med Sci. 2011; 26(4):540–5.

20. Oh HJ, Kim MH, Kwon YR, Kim HW, Kim MJ, Kim YS. A cross-sectional study of the association between thyroid hormones and thyroid-stimulating hormone with parameters of the metabolic syndrome in Korean men and women. Korean J Fam Pract. 2018; 8(5):764–70.

21. Lee JY, Kim JH, Ju MK, Kim JS, Park MH. The association between thyroid stimulating hormone and metabolic syndrome in Korean: the 6th Korean National Health and Nutrition Examination Survey (2015). Korean J Fam Pract. 2018; 8(6):877–81.

22. Mirhosseini N, Brunel L, Muscogiuri G, Kimball S. Physiological serum 25-hydroxyvitamin D concentrations are associated with improved thyroid function-observations from community-based program. Endocrine. 2017; 58(3):563–73.