Diabetes Metab J.  2020 Apr;44(2):277-285. 10.4093/dmj.2019.0008.

Intra-Abdominal Fat and High Density Lipoprotein Cholesterol Are Associated in a Non-Linear Pattern in Japanese-Americans

Affiliations
  • 1Epidemiologic Research and Information Center, VA Puget Sound Health Care System, Seattle, WA, USA
  • 2Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA,
  • 3Division of Endocrinology and Metabolism, Department of Internal Medicine, National Health Insurance Service Ilsan Hospital, Goyang, Korea
  • 4Division of Endocrinology and Metabolism, Department of Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea
  • 5Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA
  • 6Hospital and Specialty Medicine Service, VA Puget Sound Health Care System, Seattle, WA, USA
  • 7Department of Anthropology, University of Washington, Seattle, WA, USA

Abstract

Background
We describe the association between high density lipoprotein cholesterol (HDL-C) concentration and computed tomography (CT)-measured fat depots.
Methods
We examined the cross-sectional associations between HDL-C concentration and intra-abdominal (IAF), abdominal subcutaneous (SCF), and thigh fat (TF) areas in 641 Japanese-American men and women. IAF, SCF, and TF were measured by CT at the level of the umbilicus and mid-thigh. The associations between fat area measurements and HDL-C were examined using multivariate linear regression analysis adjusting for age, sex, diabetes family history, homeostasis model assessment of insulin resistance (HOMA-IR), and body mass index (BMI). Non-linearity was assessed using fractional polynomials.
Results
Mean±standard deviation of HDL-C concentration and IAF in men and women were 1.30±0.34 mg/dL, 105±55.3 cm2, and 1.67±0.43 mg/dL, 74.4±46.6 cm2 and differed significantly by gender for both comparisons (P<0.001). In univariate analysis, HDL-C concentration was significantly associated with CT-measured fat depots. In multivariate analysis, IAF was significantly and non-linearly associated with HDL-C concentration adjusted for age, sex, BMI, HOMA-IR, SCF, and TF (IAF: β=–0.1012, P <0.001; IAF2: β=0.0008, P<0.001). SCF was also negatively and linearly associated with HDL-C (β=–0.4919, P=0.001).
Conclusion
HDL-C does not linearly decline with increasing IAF in Japanese-Americans. A more complex pattern better fits this association.

Keyword

Cholesterol, HDL; Epidemiology; Intra-abdominal fat; Japanese American

Figure

  • Fig. 1 (A) Association between high density lipoprotein cholesterol (HDL-C) and intra-abdominal fat (IAF) after adjusting for age, sex, body mass index (BMI), and homeostasis model assessment of insulin resistance (HOMA-IR). The X axis denotes IAF (cm2) and the Y axis denotes the partial residual (predicted value+residual) of HDL-C concentration (mmol/L) from the regression of IAF (cm2) value while adjusting for age, sex, BMI, and HOMA-IR. Shaded regions denote 95% confidence interval for the modeled curvilinear association. (B) Association between HDL-C and IAF after adjusting for age, sex, BMI, HOMA-IR, Abdomen subcutaneous fat (SCF), and thigh fat (TF). Association between HDL-C and IAF after adjusting age, sex, BMI, HOMA-IR, SCF, and TF. The X axis denotes IAF (cm2) and the Y axis denotes the partial residual (predicted value+residual) of HDL-C concentration (mmol/L) from the regression of IAF (cm2) value while adjusting for age, sex, BMI, HOMA-IR, SCF, and TF. Shaded regions denote 95% confidence interval for the modeled curvilinear association.


Cited by  1 articles

Lower High-Density Lipoprotein Cholesterol Concentration Is Independently Associated with Greater Future Accumulation of Intra-Abdominal Fat
Sun Ok Song, You-Cheol Hwang, Han Uk Ryu, Steven E. Kahn, Donna L. Leonetti, Wilfred Y. Fujimoto, Edward J. Boyko
Endocrinol Metab. 2021;36(4):835-844.    doi: 10.3803/EnM.2021.1130.


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