Clin Psychopharmacol Neurosci.  2020 May;18(2):174-187. 10.9758/cpn.2020.18.2.174.

The Role of the SLC Transporters Protein in the Neurodegenerative Disorders

• Aykaç A
• Şehirli A

• KMID: 2502143
• DOI: http://doi.org/10.9758/cpn.2020.18.2.174

Abstract

The solute carrier (SLC) superfamily is one of the major sub-groups of membrane proteins in mammalian cells. The solute carrier proteins include more than 400 different membrane-spanning solute carriers organized with 65 families in the human. In solute carrier family neurons, neurotransmitter is considered to be a pharmacological target of neuropsychiatric drugs because of their important role in the recovery of neurotransmitters such as GABA, glutamate, serotonin, dopamine and noradrenaline and regulation of their concentration in synaptic regions. Therefore, solute carrier transporters play vital and different roles in neurodegenerative disorders. In this article, the role of solute carrier transporters in neurodegenerative disorders such as Alzheimer disease, amyotrophic lateral sclerosis, Huntington disease, Parkinson’s diseases, depression, post-traumatic stress disorder, dementia, schizophrenia, and Epilepsy reviewed and discussed to see how defects or absences in SLC transporter cause neurodegenerative disorders. In this review, we try to summarize what is known about solute carriers with respect to brain distribution and expression. The review summarizes current knowledge on the roles of solute carrier transporters in neurodegenerative disorders.

Keyword

Solute carrier; Amyotrophic lateral sclerosis; Alzheimer disease; Post-traumatic stress disorder; Depression