Korean J Fam Med.
2020 May;41(3):189-194. 10.4082/kjfm.18.0205.
The Association between Serum Uric Acid and Peripheral Neuropathy in Patients with Type 2 Diabetes Mellitus: A Multicenter Nationwide CrossSectional Study
- Kaewput W
1 - Thongprayoon C2
- Rangsin R1
- Jindarat S3
- Narindrarangkura P4
- Bathini T5
- Mao MA2
- Cheungpasitporn W6
- Affiliations
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- 1Department of Military and Community Medicine, Phramongkutklao College of Medicine, Bangkok, Thailand
- 2Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN, USA
- 3Department of Pharmacology, Phramongkutklao College of Medicine, Bangkok, Thailand
- 4iDAS Lab, Informatics Institute, University of Missouri, Columbia, MO, USA
- 5Department of Internal Medicine, University of Arizona, Tucson, AZ, USA
- 6Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA
- KMID: 2501867
- DOI: http://doi.org/10.4082/kjfm.18.0205
Abstract
- Background
The role of uric acid in the development of diabetic peripheral neuropathy remains unclear. This study aimed to determine the association between uric acid and peripheral neuropathy among type 2 diabetes mellitus (T2DM) patients.
Methods
We conducted a nationwide cross-sectional study based on the diabetes and hypertension study of the Medical Research Network of the Consortium of Thai Medical Schools. Adult T2DM patients from 831 public hospitals in Thailand were evaluated. The serum uric acid level was categorized into five groups based on quintiles (<4.4, 4.4–5.3, 5.3–6.2, 6.2–7.3, and >7.3 mg/dL). A multivariate logistic regression model was used to assess the independent association between serum uric acid level and peripheral neuropathy.
Results
In total, 7,511 T2DM patients with available data about serum uric acid levels were included in the analysis. The mean age of the participants was 61.7±10.9 years, and approximately 35.6% were men. The prevalence rate of peripheral neuropathy was 3.0%. Moreover, the prevalence rates of peripheral neuropathy stratified according to uric acid levels <4.4, 4.4–5.3, 5.3–6.2, 6.2–7.3, and >7.3 mg/dL were 2.5%, 2.8%, 2.4%, 2.5%, and 4.7%, respectively. A serum uric acid level ≥7.3 mg/dL was found to be associated with an increase in odds ratio (1.54; 95% confidence interval, 1.02–2.32) for peripheral neuropathy compared with a serum uric acid level <4.4 mg/dL.
Conclusion
Serum uric acid level is independently associated with peripheral neuropathy in T2DM patients, and elevated serum uric acid levels should be considered a risk factor for diabetic peripheral neuropathy in clinical practice.
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