J Korean Neurol Assoc.  2020 Feb;38(1):25-28. 10.17340/jkna.2020.1.4.

Late-Onset Wilson’s Disease Mimics Hashimoto Encephalopathy

Affiliations
  • 1Department of Neurology, Pusan National University School of Medicine, Busan, Korea
  • 2Biomedical Research Institute, Pusan National University Hospital, Busan, Korea

Abstract

A 48-year-old woman presented with a 1-day history of aggressive behavior. Hashimoto encephalopathy was first suspected based on elevated levels of serum anti-thyroid peroxidase antibody. Her clinical symptoms did not improve despite treatment with intravenous corticosteroid. Abdominal computed tomography revealed liver cirrhosis, and brain T2-weighted magnetic resonance imaging revealed midbrain hyperintensity, and she was finally diagnosed with Wilson’s disease. The Wilson’s disease should be considered in the differential diagnosis in adults presenting with unexplained hepatic, neurological, or psychiatric abnormalities.

Keyword

Wilson’s disease; Liver cirrhosis; Copper
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