J Korean Ophthalmol Soc.  2020 May;61(5):482-490. 10.3341/jkos.2020.61.5.482.

Analyses of Vessel Densities and Foveal Avascular Zones Using Four Optical Coherence Tomography Angiography Devices

• Park SY
• Nam KT
• Yun C
• Jang S

• KMID: 2500720
• DOI: http://doi.org/10.3341/jkos.2020.61.5.482

Abstract

Purpose
To compare the vessel density (VD) and foveal avascular zone (FAZ) area using four different optical coherence tomography angiography (OCTA) images.
Methods
This prospective study analyzed the OCTA images of consecutive healthy subjects using Plex-Elite (Carl Zeiss), DRI OCT-1 Atlantis (Topcon), AngioPlex (Carl Zeiss), and Spectralis OCTA (Heidelberg Engineering). The VD and FAZ areas were calculated using the OCTA images with a 3 x 3 mm2 volume scan pattern centered on the fovea.
Results
The VD (%) of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) were different using the four devices: Plex-Elite (42.17 ± 2.79, 43.71 ± 2.36), DRI OCT-1 Atlantis (28.70 ± 2.87, 30.27 ± 3.02), AngioPlex (28.32 ± 6.68, 33.33 ± 5.44), and Spectralis OCTA (27.86 ± 4.13, 28.54 ± 3.14), respectively; p < 0.001). The FAZ area (mm2) of the SCP and DCP were different using the four devices: Plex-Elite (0.276 ± 0.097, 0.340 ± 0.100), DRI OCT-1 Atlantis (0.281 ± 0.102, 0.354 ± 0.119), AngioPlex (0.269 ± 0.099, 0.422 ± 0.120), and Spectralis OCTA (0.272 ± 0.079, 0.298 ± 0.106), respectively; p < 0.001). The VD of the SCP and DCP had no significant correlation using the four devices (all, p > 0.05), but the FAZ area had positive correlations using the four devices (all, p < 0.001).
Conclusions
The four OCTA devices provided different VD and FAZ areas, so these differences should be considered in analyzing OCTA images.

Keyword

Foveal avascular zone; Optical coherence tomography angiography; Vessel density