Clin Exp Otorhinolaryngol.  2020 May;13(2):133-140. 10.21053/ceo.2019.00801.

Changes in Cortical Auditory Evoked Potentials by Ipsilateral, Contralateral and Binaural Speech Stimulation in Normal-Hearing Adults

Affiliations
  • 1Department of Otorhinolaryngology-Head and Neck Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
  • 2Department of Otorhinolaryngology-Head and Neck Surgery, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea

Abstract


Objectives
. Cortical auditory evoked potentials (CAEPs) have been used to examine auditory cortical development or changes in patients with hearing loss. However, there have been no studies analyzing CAEP responses to the different sound stimulation by different stimulation sides. We characterized changes in normal CAEP responses by stimulation sides in normal-hearing adults.
Methods
. CAEPs from the right auditory cortex were recorded in 16 adults following unilateral (ipsilateral and contralateral) and bilateral sound stimulation using three speech sounds (/m/, /g/, and /t/). Amplitudes and latencies of the CAEP peaks in three conditions were compared.
Results
. Contralateral stimulation elicited larger P2-N1 amplitudes (sum of P2 and N1 amplitudes) than ipsilateral stimulation regardless of the stimulation sounds, mostly due to the larger P2 amplitudes obtained, but elicited comparable P2-N1 amplitudes to bilateral stimulation. Although the P2-N1 amplitudes obtained with the three speech sounds were comparable following contralateral stimulation, the /m/ sound elicited the largest P2-N1 amplitude in ipsilateral stimulation condition due to the largest N1 amplitude obtained, whereas /t/ elicited larger a P2-N1 amplitude than /g/ in bilateral stimulation condition due to a larger P2 amplitude.
Conclusion
. Spectrally different speech sounds and input sides are encoded differently at the cortical level in normal-hearing adults. Standardized speech stimuli, as well as specific input sides of speech, are needed to examine normal development or rehabilitation-related changes of the auditory cortex in the future.

Keyword

Auditory Cortex; Evoked Potentials; Hearing Test; Hearing Loss; Acoustic Stimulation

Figure

  • Fig. 1. Cortical auditory evoked potential (CAEP) waveforms in a normal hearing subject. In ipsilateral sound stimulation (A), contralateral sound stimulation (B), and bilateral sound stimulation (C), the actual CAEP waveforms for three natural speech sounds (/m/, /g/, and /t/) at 65 dB SPL are shown.

  • Fig. 2. Changes in P2-N1 waveform amplitudes by input side (A) and speech sound type (B) in normal-hearing adults. Ipsi, ipsilateral; Contra, contralateral; Bi, bilateral. Repeated measures analysis of variance with post-hoc Bonferroni, *P<0.05, **P<0.01, ***P<0.001.

  • Fig. 3. Changes in amplitudes (A) and latencies (B) of the cortical auditory evoked potentials responses by input side of speech stimulation in normal-hearing adults. The N1 peak amplitudes were converted to positive values, which are shown as a mean±standard error of mean. Repeated measures analysis of variance with post-hoc Bonferroni, *P<0.05, **P<0.01, ***P<0.001.

  • Fig. 4. Changes in amplitudes (A) and latencies (B) of the cortical auditory evoked potential responses by speech sound type in normal-hearing adults. The N1 peak amplitudes were converted to positive values, which are shown as a mean±standard error of mean. Repeated measures analysis of variance with post-hoc Bonferroni, *P<0.05, **P<0.01, ***P<0.001.


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