Brain Tumor Res Treat.  2020 Apr;8(1):66-70. 10.14791/btrt.2020.8.e4.

Pineal Cyst Apoplexy: A Rare Complication of Common Entity

Affiliations
  • 1Department of Neurosurgery, Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea

Abstract

Pineal cysts (PCs) are often encountered as incidental findings in intracranial images. The vast majority of cysts are normally asymptomatic and clinically benign. Bleeding into the cysts, which leads to neurological symptoms and signs, is considered to be quite rare. The authors illustrate a newly identified complication of PC in a 56-year-old woman who characterized by headache of sudden onset and vomiting. MRI disclosed a small hemorrhagic PC without narrowing of the cerebral aqueduct. The patient was managed conservatively without any surgical interventions, and she remained symptom-free over a period of 15-year follow-up. The description of this case adds to the limited literature on the series in which nonsurgical treatments had a role in the care for patients with PC complicated by intracystic hemorrhage.

Keyword

Apoplexy; Pineal cyst; Pineal gland

Figure

  • Fig. 1 CT scans of pineal cyst apoplexy. The ventricle width is normal (A) and the cyst is mildly enhanced at the periphery (B).

  • Fig. 2 MRI for pineal cyst (PC) apoplexy. A: Initial examinations display the PC measuring 11×9×7 mm with incomplete rim enhancement. B: The dorsal midbrain remains intact, and the cerebral aqueduct is patent. C: The sign of hemorrhage is visible on gradient echo sequence image. D, E: MR series taken from lying supine and inclined at 45 degrees depict fluid-blood level within the cyst suggesting intracystic hemorrhage. F: At the 15-year follow-up post-apoplexy, the scan reveals the stable cyst with hemosiderin stains in the pineal body.


Reference

1. Al-Holou WN, Terman SW, Kilburg C, et al. Prevalence and natural history of pineal cysts in adults. J Neurosurg. 2011; 115:1106–1114. PMID: 21780858.
2. Kalani MY, Wilson DA, Koechlin NO, et al. Pineal cyst resection in the absence of ventriculomegaly or Parinaud's syndrome: clinical outcomes and implications for patient selection. J Neurosurg. 2015; 123:352–356. PMID: 25932610.
3. Osborn RE, Deen HG, Kerber CW, Glass RF. A case of hemorrhagic pineal cyst: MR/CT correlation. Neuroradiology. 1989; 31:187–189. PMID: 2747899.
4. Tamura Y, Yamada Y, Tucker A, et al. Endoscopic surgery for hemorrhagic pineal cyst following antiplatelet therapy: case report. Neurol Med Chir (Tokyo). 2013; 53:625–629. PMID: 24067776.
5. Asundi A, Tampieri D, Melançon D, Del Maestro R, Petrecca K, Cortes MD. Pineal apoplexy: imaging diagnosis and follow-up of three new cases. Can J Neurol Sci. 2011; 38:931–933. PMID: 22030436.
6. Mehrzad R, Mishra S, Feinstein A, Ho MG. A new identified complication of intracystic hemorrhage in a large pineal gland cyst. Clin Imaging. 2014; 38:515–517. PMID: 24746445.
7. Patel AJ, Fuller GN, Wildrick DM, Sawaya R. Pineal cyst apoplexy: case report and review of the literature. Neurosurgery. 2005; 57:E1066. discussion E1066. PMID: 16284546.
8. Storey M, Lilimpakis K, Grandal NS, Rajaraman C, Achawal S, Hussain M. Pineal cyst surveillance in adults - a review of 10 years' experience. Br J Neurosurg. 2019; DOI: 10.1080/02688697.2019.1635989. [Epub].
9. Barboriak DP, Lee L, Provenzale JM. Serial MR imaging of pineal cysts: implications for natural history and follow-up. AJR Am J Roentgenol. 2001; 176:737–743. PMID: 11222216.
10. Yamamoto K, Omodaka T, Watanabe R, Kodaira M. A hemorrhagic pineal cyst with a bacterial meningitis-like manifestation and benign outcome. Intern Med. 2013; 52:2817–2820. PMID: 24334592.
11. Sarikaya-Seiwert S, Turowski B, Hänggi D, Janssen G, Steiger HJ, Stummer W. Symptomatic intracystic hemorrhage in pineal cysts. Report of 3 cases. J Neurosurg Pediatr. 2009; 4:130–136. PMID: 19645546.
12. Wisoff JH, Epstein F. Surgical management of symptomatic pineal cysts. J Neurosurg. 1992; 77:896–900. PMID: 1432132.
13. Michielsen G, Benoit Y, Baert E, Meire F, Caemaert J. Symptomatic pineal cysts: clinical manifestations and management. Acta Neurochir (Wien). 2002; 144:233–242. discussion 242. PMID: 11956936.
14. Mukherjee KK, Banerji D, Sharma R. Pineal cyst presenting with intracystic and subarachnoid haemorrhage: report of a case and review of the literature. Br J Neurosurg. 1999; 13:189–192. PMID: 10616590.
15. Swaroop GR, Whittle IR. Pineal apoplexy: an occurrence with no diagnostic clinicopathological features. Br J Neurosurg. 1998; 12:274–276. PMID: 11013695.
16. Mattogno PP, Frassanito P, Massimi L, et al. Spontaneous regression of pineal lesions: ghost tumor or pineal apoplexy? World Neurosurg. 2016; 88:64–69. PMID: 26748174.
17. Milroy CM, Smith CL. Sudden death due to a glial cyst of the pineal gland. J Clin Pathol. 1996; 49:267–269. PMID: 8675746.
18. Apuzzo ML, Davey LM, Manuelidis EE. Pineal apoplexy associated with anticoagulant therapy. Case report. J Neurosurg. 1976; 45:223–226. PMID: 59801.
19. Avery GJ, Lind CR, Bok AP. Successful conservative operative management of pineal apoplexy. J Clin Neurosci. 2004; 11:667–669. PMID: 15261249.
20. Richardson JK, Hirsch CS. Sudden, unexpected death due to “pineal apoplexy”. Am J Forensic Med Pathol. 1986; 7:64–68. PMID: 3728423.
21. Werder GM, Razdan RS, Gagliardi JA, Chaddha SKB. Conservatively managed pineal apoplexy in an anticoagulated patient. Radiography. 2008; 14:69–72.
22. Fain JS, Tomlinson FH, Scheithauer BW, et al. Symptomatic glial cysts of the pineal gland. J Neurosurg. 1994; 80:454–460. PMID: 8113858.
23. Mena H, Armonda RA, Ribas JL, Ondra SL, Rushing EJ. Nonneoplastic pineal cysts: a clinicopathologic study of twenty-one cases. Ann Diagn Pathol. 1997; 1:11–18. PMID: 9869821.
24. Pastel DA, Mamourian AC, Duhaime AC. Internal structure in pineal cysts on high-resolution magnetic resonance imaging: not a sign of malignancy. J Neurosurg Pediatr. 2009; 4:81–84. PMID: 19569915.
25. Choy W, Kim W, Spasic M, Voth B, Yew A, Yang I. Pineal cyst: a review of clinical and radiological features. Neurosurg Clin N Am. 2011; 22:341–351. PMID: 21801982.
26. Engel U, Gottschalk S, Niehaus L, et al. Cystic lesions of the pineal region--MRI and pathology. Neuroradiology. 2000; 42:399–402. PMID: 10929297.
27. Higashi K, Katayama S, Orita T. Pineal apoplexy. J Neurol Neurosurg Psychiatry. 1979; 42:1050–1053. PMID: 501370.
28. Koenigsberg RA, Faro S, Marino R, Turz A, Goldman W. Imaging of pineal apoplexy. Clin Imaging. 1996; 20:91–94. PMID: 8744815.
29. Gokce E, Beyhan M. Evaluation of pineal cysts with magnetic resonance imaging. World J Radiol. 2018; 10:65–77. PMID: 30079153.
30. Fleege MA, Miller GM, Fletcher GP, Fain JS, Scheithauer BW. Benign glial cysts of the pineal gland: unusual imaging characteristics with histologic correlation. AJNR Am J Neuroradiol. 1994; 15:161–166. PMID: 8141049.
31. Fakhran S, Escott EJ. Pineocytoma mimicking a pineal cyst on imaging: true diagnostic dilemma or a case of incomplete imaging. AJNR Am J Neuroradiol. 2008; 29:159–163. PMID: 17925371.
32. Deiana G, Mottolese C, Hermier M, Louis-Tisserand G, Berthezene Y. Imagery of pineal tumors. Neurochirurgie. 2015; 61:113–122. PMID: 25676911.
33. Nolte I, Brockmann MA, Gerigk L, Groden C, Scharf J. TrueFISP imaging of the pineal gland: more cysts and more abnormalities. Clin Neurol Neurosurg. 2010; 112:204–208. PMID: 20034731.
34. Májovský M, Netuka D, Beneš V. Conservative and surgical treatment of patients with pineal cysts: prospective case series of 110 patients. World Neurosurg. 2017; 105:199–205. PMID: 28583453.
35. Ayhan S, Bal E, Palaoglu S, Cila A. Pineal cyst apoplexy: report of an unusual case managed conservatively. Neurol Neurochir Pol. 2011; 45:604–607. PMID: 22212992.
36. McNeely PD, Howes WJ, Mehta V. Pineal apoplexy: is it a facilitator for the development of pineal cysts. Can J Neurol Sci. 2003; 30:67–71. PMID: 12619788.
37. Nimmagadda A, Sandberg DI, Ragheb J. Spontaneous involution of a large pineal region hemorrhagic cyst in an infant. Case report. J Neurosurg. 2006; 104(4 Suppl):275–278. PMID: 16619640.
Full Text Links
  • BTRT
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr