J Korean Acad Prosthodont.  2020 Apr;58(2):77-85. 10.4047/jkap.2020.58.2.77.

The Effect of N-acetyl cysteine (NAC) loading on the bone formation surrounding sandblastedand large-grit and acid-etched implants in the dog: A pilot study

• Seo JM
• Kim IJ
• Bae MS
• Lee JJ
• Ahn SG

• KMID: 2500019
• DOI: http://doi.org/10.4047/jkap.2020.58.2.77

Abstract

Purpose
The aim of the present study was to investigate the effects of N-acetyl cysteine (NAC) loading on the bone formation surrounding sandblasted, large-grit and acidetched (SLA) implants. Materials and methods: Implantation of NAC loaded SLA implants (NSI group) and SLA implants (SI group) was performed bilaterally in the mandible of 4 adult beagle dogs (each group, n = 8). The animals were sacrificed after a healing period of 3 and 6 weeks, respectively (n = 2 animal each). Dissected blocks were processed for histomorphometrical analysis. Bone to implant contact percentage (BIC%) and bone volume (BV%) were assessed histomorphometrically. Results: BIC% of NAC loaded SLA implants were about 50% higher than that of SLA implants at 3 weeks of bone healing, but not significantly (51.79 vs 35.43%; P=.185). BV% of NAC loaded SLA implants were significantly higher than that of SLA implants at 3 weeks of bone healing (45.09 vs 37.57 %; P=.044). At 6 weeks of bone healing, BIC% and BV% of two experimental groups were similar (P>.05). Conclusion: Within the limits of the present study, NAC loading have a positive effects on the early bone formation surrounding SLA implants. So, it might be concluded that NAC loading enhance the osseointegration and shorten the healing time after implantation of the SLA implants. (J Korean Acad Prosthodont 2020;58:77-85)

Keyword

Implant; N-acetyl cysteine (NAC); Sandblasted and large-grit and acid-etched