J Rheum Dis.  2020 Apr;27(2):110-115. 10.4078/jrd.2020.27.2.110.

Circulating Interleukin-18 Level in Systemic Lupus Erythematosus

Affiliations
  • 1Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea. lyhcgh@korea.ac.kr

Abstract


OBJECTIVE
This study aimed to evaluate the relationship between circulating interleukin (IL)-18 levels and systemic lupus erythematosus (SLE) and establish a correlation between plasma/serum IL-18 levels and SLE activity.
METHODS
We performed a meta-analysis comparing plasma/serum IL-18 levels in patients with SLE to controls by using fixed or random effects model based on the heterogeneity.
RESULTS
Sixteen studies with 659 SLE patients and 502 controls were included in this meta-analysis. Meta-analysis showed that IL-18 levels were significantly higher in the SLE group (standardized mean difference=1.556, 95% confidence interval=1.087~2.024, p<0.001). Stratifying by ethnicity showed that IL-18 levels were significantly elevated in the SLE groups of European, Asian, and Arab populations. Stratification by adjustment for age and/or sex revealed a significantly higher IL-18 level in the SLE group, independently of the adjustment. Subgroup analysis by sample size showed significantly higher IL-18 levels in the SLE group for both large sample (n≥50) and small sample (n<50) subgroups. Subgroup analysis by data type showed significantly higher IL-18 levels in the SLE group for both original and calculated data populations.
CONCLUSION
This meta-analysis demonstrated that circulating IL-18 levels are higher in patients with SLE.

Keyword

Association; Lupus erythematosus, systemic; Interleukin-18

MeSH Terms

Arabs
Asian Continental Ancestry Group
Humans
Interleukin-18*
Interleukins
Lupus Erythematosus, Systemic*
Population Characteristics
Sample Size
Interleukin-18
Interleukins
Full Text Links
  • JRD
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
    DB Error: unknown error