J Rheum Dis.  2020 Apr;27(2):100-109. 10.4078/jrd.2020.27.2.100.

Comparison of Clinical, Angiographic Features and Outcome in Takayasu's Arteritis and Behçet's Disease With Arterial Involvement

• Choi SJ
• Koo HJ
• Yang DH
• Kang JW
• Oh JS
• Hong S
• Kim YG
• Yoo B
• Lee CK

• KMID: 2471951
• DOI: http://doi.org/10.4078/jrd.2020.27.2.100

Abstract

OBJECTIVE
Takayasu's arteritis (TAK) is a vasculitis that primarily involves the aorta and its branches. In Behçet's disease (BD), systemic vasculitis is one of major manifestations. We aimed to compare clinical and angiographic features and outcome between TAK and BD with arterial involvement.
METHODS
We retrospectively reviewed medical records of 206 TAK patients and 50 BD patients between 1995 and 2015. Angiographic lesions were evaluated via computed tomography, magnetic resonance imaging, and/or conventional angiography.
RESULTS
Fever (30% vs. 9.2%, p<0.001) and arthralgia (36% vs. 7.3%, p<0.001) were more common in BD. C-reactive protein was higher in BD compared with TAK (5.85 mg/dL vs. 2.08 mg/dL, p<0.001). Stenosis (89.8% vs. 60%, p<0.001) and occlusion (65.5% vs. 32%, p<0.001) were more observed in TAK. In contrast, aneurysm was common in BD (62% vs. 20.9%, p<0.001). The carotid artery (73.3% vs. 30%, p<0.001), subclavian artery (71.4% vs. 16%, p<0.001), descending aorta (35% vs. 12%, p=0.002), renal artery (23.8% vs. 10%, p=0.032), superior mesenteric artery (18.4% vs. 4%, p=0.012), and brachiocephalic trunk (13.6% vs. 2%, p=0.020) were more commonly involved in TAK, whereas the femoral artery (10% vs. 2.4%, p=0.027) was more frequently involved in BD. During follow-up, arterial dissection (10% vs. 1.9%, p=0.016), rupture (12% vs. 0.5%, p<0.001), and arterial replacement/resection (66% vs. 9.7%, p<0.001) were more observed in BD.
CONCLUSION
TAK differs from BD regarding clinical features and vascular involvement patterns. BD exhibits a higher rate of vascular complications.

Keyword

Behcet syndrome; Takayasu arteritis; Arteritis; Cardiovascular diseases

MeSH Terms

Aneurysm
Angiography
Aorta
Aorta, Thoracic
Arteritis
Arthralgia
Behcet Syndrome
Brachiocephalic Trunk
C-Reactive Protein
Cardiovascular Diseases
Carotid Arteries
Constriction, Pathologic
Femoral Artery
Fever
Follow-Up Studies
Humans
Magnetic Resonance Imaging
Medical Records
Mesenteric Artery, Superior
Renal Artery
Retrospective Studies
Rupture
Subclavian Artery
Systemic Vasculitis
Takayasu Arteritis*
Vasculitis
C-Reactive Protein

Figure

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  Figure 1. Study participants in Takayasu's arteritis (TAK) and Behçet's disease (BD). ICBD: International Criteria for Behçet's disease.

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  Figure 2. Pattern of angiographic features in Takayasu's arteritis (TAK) and Behçet's disease (BD) according to distribution region. Results presented as number (%). *p<0.05, **p<0.01, and ***p<0.001.

• 

  Figure 3. Arterial involvement in Takayasu's arteritis (TAK) and Behçet's disease (BD) according to distribution. Results presented as number (%). *p<0.05, **p<0.01, and ***p<0.001.

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