Tuberc Respir Dis.  2020 Apr;83(2):157-166. 10.4046/trd.2019.0037.

Risk Factor and Mortality in Patients with Pulmonary Embolism Combined with Infectious Disease

• Lee GD
• Ju S
• Kim JY
• Kim TH
• Yoo JW
• Lee SJ
• Cho YJ
• Jeong YY
• Jeon KN
• Lee JD
• Kim HC

• KMID: 2471892
• DOI: http://doi.org/10.4046/trd.2019.0037

Abstract

BACKGROUND
Infectious conditions may increase the risk of venous thromboembolism. The purpose of this study was to evaluate the risk factor for combined infectious disease and its influence on mortality in patients with pulmonary embolism (PE).
METHODS
Patients with PE diagnosed based on spiral computed tomography findings of the chest were retrospectively analyzed. They were classified into two groups: patients who developed PE in the setting of infectious disease or those with PE without infection based on review of their medical charts.
RESULTS
Of 258 patients with PE, 67 (25.9%) were considered as having PE combined with infectious disease. The sites of infections were the respiratory tract in 52 patients (77.6%), genitourinary tract in three patients (4.5%), and hepatobiliary tract in three patients (4.5%). Underlying lung disease (odds ratio [OR], 3.69; 95% confidence interval [CI], 1.926-7.081; p<0.001), bed-ridden state (OR, 2.84; 95% CI, 1.390-5.811; p=0.004), and malignant disease (OR, 1.867; 95% CI, 1.017-3.425; p=0.044) were associated with combined infectious disease in patients with PE. In-hospital mortality was higher in patients with PE combined with infectious disease than in those with PE without infection (24.6% vs. 11.0%, p=0.006). In the multivariate analysis, combined infectious disease (OR, 4.189; 95% CI, 1.692-10.372; p=0.002) were associated with non-survivors in patients with PE.
CONCLUSION
A substantial portion of patients with PE has concomitant infectious disease and it may contribute a mortality in patients with PE.

Keyword

Pulmonary Embolism; Infectious Disease; Mortality

MeSH Terms

Communicable Diseases*
Hospital Mortality
Humans
Lung Diseases
Mortality*
Multivariate Analysis
Pulmonary Embolism*
Respiratory System
Retrospective Studies
Risk Factors*
Thorax
Tomography, Spiral Computed
Venous Thromboembolism

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