J Bacteriol Virol.  2020 Mar;50(1):55-63. 10.4167/jbv.2020.50.1.055.

Anticoccidial Effect of CS 32 Compounds Against Eimeria tenella Infection in Chickens

• Jang K
• Kim SE
• Shim KM
• Park HJ
• Kim S
• Min W
• Yoo JC
• Kang SS

• KMID: 2471838
• DOI: http://doi.org/10.4167/jbv.2020.50.1.055

Abstract

Coccidiosis-causing Eimeria species are transmitted in poultry via the oral-fecal route and can lead to hemorrhagic diarrhea and mortality. This results in enormous economic losses in the poultry industry. Furthermore, its resistance to some currently used antibiotics is increasing. This has prompted the development of new alternative drug therapies that address the issue of chemical-free meat production. Effective management of infectious diseases in veterinary practice includes the induction of protective and adaptive immunity by treatment with an alternative agent. In this study, we evaluated the anticoccidial effects of dietary supplementation of Chosun University (CS) 32 compounds (0.1% and 1.0%) against Eimeria tenella, which was isolated and purified from the supernatant of culture broth of Bacillus strain (KCTC18250P), as well as its effect on the growth rate and feed efficiency in chickens. Overall, we observed a decrease in lesion scores and oocyte output in CS 32 compounds-treated chickens. We concluded that 0.1% CS 32 compounds displayed anticoccidial effects against E. tenella infection.

Keyword

CS 32 compounds; anticoccidial effect; E. tenella; chickens

MeSH Terms

Adaptive Immunity
Anti-Bacterial Agents
Bacillus
Chickens*
Communicable Diseases
Diarrhea
Dietary Supplements
Drug Therapy
Eimeria tenella*
Eimeria*
Meat Products
Mortality
Oocytes
Poultry
Anti-Bacterial Agents

Figure

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  Fig. 1. Effects of dietary supplementation with CS 32 compounds on weight gains after challenged with E tenella. NC: neg ative control (uninfected and untreated group); PC: positive control (infected and untreated group); 0.1%: 0.1% CS 32 co impounds group (infected and treated with 0.1% CS 32 compounds); 1.0%: 1.0% CS 32 compounds group (infected and treated with 1.0% CS 32 compounds); n=28 for days 0 and 5, and n=21 for days 10.

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  Fig. 2. Effects of dietary supplementation with CS 32 compounds on oocyte output after challenged with E tenella from days 6 to 10 p.i. NC: negative control (uninfected and untreated group); PC: positive control (infected and untreated group); 0.1%: 0.1% CS 32 compounds group (infected and treated with 0.1% CS 32 compounds); 1.0%: 1.0% CS 32 compounds group (infected and treated with 1.0% CS 32 compounds); n=21 for each group. ∗Significant difference (P<0.05) between PC and 0.1% CS 32 compounds groups.

• 

  Fig. 3. Effects of dietary supplementation with CS 32 compounds on lesion score after challenged with E. tenella at 5 days p.i. NC: negative control (uninfected and untreated group); PC: positive control (infected and untreated group); 0.1%: 0.1% CS 32 compounds group (infected and treated with 0.1% CS 32 compounds); 1.0%: 1.0% CS 32 compounds group (infected and treated with 1.0% CS 32 compounds); n=7 for each group. ∗Significant difference (P<0.05) between PC and 0.1% CS 32 compounds groups.

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