J Dent Anesth Pain Med.  2020 Feb;20(1):19-27. 10.17245/jdapm.2020.20.1.19.

Comparison of safety and analgesic efficacy of diclofenac sodium with etodolac after surgical extraction of third molars: a randomized, double-blind, double-dummy, parallel-group study

• Vaghela JH
• Shah JH
• Patel JH
• Purohit BM

• KMID: 2471170
• DOI: http://doi.org/10.17245/jdapm.2020.20.1.19

Abstract

BACKGROUND
Surgical extraction of third molars is associated with postoperative pain and swelling at the extraction site. Pain is commonly managed using non-steroidal anti-inflammatory drugs (NSAIDs). Postoperative pain is usually moderate to severe in the first 12 h postoperatively and lasts for 3-5 days. However, with NSAIDs, these symptoms usually subside within 24 h. Diclofenac sodium and etodolac are NSAIDs, more selectively cyclooxygenase-2 inhibitors, with good analgesic efficacies.
METHODS
We compared the safety and analgesic efficacy of diclofenac sodium with etodolac peroral after surgical extraction of third molars in a double-blind, double-dummy, parallel-group study. The subjective pain improvement and pain relief after 2, 6, 24, 48, and 72 h using the visual analogue scale were measured as the study outcome.
RESULTS
Etodolac was equivalent to diclofenac sodium in pain alleviation at all postoperative time periods. No significant differences were found between diclofenac sodium and etodolac groups (P > 0.05). Both study medications were well tolerated and safe with mild adverse effects in only a few participants.
CONCLUSION
Diclofenac sodium and etodolac are comparable in terms of analgesic efficacy and safety after surgical removal of third molars.

Keyword

Diclofenac; Etodolac; Pain; Third Molar; Tooth Extraction; Visual Analog Scale

MeSH Terms

Anti-Inflammatory Agents, Non-Steroidal
Cyclooxygenase 2 Inhibitors
Diclofenac*
Etodolac*
Molar, Third*
Pain, Postoperative
Tooth Extraction
Visual Analog Scale
Anti-Inflammatory Agents, Non-Steroidal
Cyclooxygenase 2 Inhibitors
Diclofenac
Etodolac

Figure

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  Fig. 1 CONSORT flowchart of participants

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  Fig. 2 Efficacy of drugs on pain depicted in a time course using the visual analogue scale

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