Korean J Psychosom Med.  2019 Dec;27(2):155-163. 10.22722/KJPM.2019.27.2.155.

Association between Cognitive function, Behavioral and Psychological Symptoms of Dementia and Temporal Lobe Atrophy in Patients with Alzheimer's Disease and Mild Cognitive Impairment

• Jeong JY
• Lee KJ
• Kim H

• KMID: 2470704
• DOI: http://doi.org/10.22722/KJPM.2019.27.2.155

Abstract

OBJECTIVES
The aim of this study was to compare severity, neurocognitive functions, and behavioral and psychological symptoms of dementia (BPSD) according to the degree of temporal lobe atrophy (MTA) in Korean patients with dementia due to Alzheimer's disease and mild cognitive impairment due to Alzheimer's disease.
METHODS
Participants were 114 elderly subjects diagnosed with Alzheimer's disease or mild cognitive impairment in this cross-sectional study. MTA in brain MRI was rated with standardized visual rating scales (Scheltens scale) and the subjects were divided into two groups according to Scheltens scale. Severity was evaluated with Clinical Dementia Rating (CDR) and Global Deterioration Scale (GDS). Neurocognitive functions was evaluated with the Korean version of Short Blessed Test (SBT-K) and the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease assessment packet (CERAD-K). BPSD was evaluated with the Korean version of the Neuropsychiatric Inventory (K-NPI). Independent t-test was performed to compare severity, neurocognitive functions, and BPSD between two groups.
RESULTS
The group with high severity of MTA showed significantly lower scores in CDR, SBT-K, MMSE-KC, modified Boston naming test, word list recognition, and word list memory (p<0.05). There were no differences in K-NPI scores between two groups.
CONCLUSIONS
Severity and neurocognitive functions of dementia had significant positive association with MTA, but BPSD had no association with MTA. Evaluating MTA seems to have potential benefit in diagnosing and treating neurocognitive impairments in the elderly. Further evaluation is needed to confirm the association between certain brain structures and BPSD.

Keyword

Alzheimer's disease; Mild cognitive impairment; Medial temporal lobe atrophy; Neurocognitive function; Behavioral psychological symptoms of dementiar

MeSH Terms

Aged
Alzheimer Disease*
Atrophy*
Brain
Cognition*
Cross-Sectional Studies
Dementia*
Humans
Magnetic Resonance Imaging
Memory
Mild Cognitive Impairment*
Pemetrexed
Temporal Lobe*
Weights and Measures
Pemetrexed