J Dig Cancer Res.  2019 Dec;7(2):57-60. 10.0000/jdcr.2019.7.2.57.

Salvage Endoscopic Resection for Residual Lesion after Definitive Chemoradiotherapy in Esophageal Cancer

• Kim SJ
• Hong R
• Lee J

• KMID: 2470443
• DOI: http://doi.org/10.0000/jdcr.2019.7.2.57

Abstract

Definitive chemoradiotherapy (CRT) with its significant efficacy and safety in esophageal cancer is reserved for patients with unresectable tumor or those who decline surgery. However, the incidence of locoregional failure or recurrence after definitive CRT remains high. Although esophagectomy is the standard treatment for locoregional failure or recurrence, this approach is associated with high mortality and morbidity. A 56-year-old man diagnosed with esophageal squamous cell carcinoma who refused to undergo surgery received definitive CRT. An endoscopy for response assessment performed after 2 months revealed a residual lesion, which was completely resected by salvage endoscopic submucosal dissection. To the best of our knowledge, endoscopic resection in locoregional failure or recurrence after definitive CRT is very rarely reported, and there are no guidelines or consensus to date. Here, we report a case of successful salvage endoscopic resection of residual lesion after definitive CRT.

Keyword

Esophageal neoplasm; Salvage therapy; Endoscopic mucosal resection; Chemoradiotherapy

MeSH Terms

Carcinoma, Squamous Cell
Chemoradiotherapy*
Consensus
Endoscopy
Esophageal Neoplasms*
Esophagectomy
Humans
Incidence
Middle Aged
Mortality
Recurrence
Salvage Therapy