Mycobiology.  2019 Dec;47(4):457-465. 10.1080/12298093.2019.1677380.

Conserved Roles of MonA in Fungal Growth and Development in Aspergillus Species

Affiliations
  • 1School of Food Science and Biotechnology, Institute of Agricultural Science and Technology, Kyungpook National University, Daegu, South Korea. phsoo97@knu.ac.kr

Abstract

MonA is a subunit of a guanine nucleotide exchange factor that is important for vacuole passing and autophagy processes in eukaryotes. In this study, we characterized the function of MonA, an orthologue of Saccharomyces cerevisiae Mon1, in the model fungus Aspergillus nidulans and a toxigenic fungus A. flavus. In A. nidulans, the absence of AnimonA led to decreased fungal growth, reduced asexual reproduction, and defective cleistothecia production. In addition, AnimonA deletion mutants exhibited decreased spore viability, had reduced trehalose contents in conidia, and were sensitive to thermal stress. In A. flavus, deletion of AflmonA caused decreased fungal growth and defective production of asexual spores and sclerotia structures. Moreover, the absence of monA affected vacuole morphology in both species. Taken together, these results indicate that MonA plays conserved roles in controlling fungal growth, development and vacuole morphology in A. nidulans and A. flavus.

Keyword

MonA; asexual development; Aspergillus nidulans; Aspergillus flavus

MeSH Terms

Aspergillus flavus
Aspergillus nidulans
Aspergillus*
Autophagy
Eukaryota
Fungi
Growth and Development*
Guanine Nucleotide Exchange Factors
Reproduction, Asexual
Saccharomyces cerevisiae
Spores
Spores, Fungal
Trehalose
Vacuoles
Guanine Nucleotide Exchange Factors
Trehalose
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