J Korean Med Sci.  2020 Feb;35(6):e79. 10.3346/jkms.2020.35.e79.

Case of the Index Patient Who Caused Tertiary Transmission of COVID-19 Infection in Korea: the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Infected Pneumonia Monitored by Quantitative RT-PCR

Affiliations
  • 1Department of Laboratory Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang, Korea.
  • 2New Horizon Cancer Institute, Myongji Hospital, Goyang, Korea.
  • 3Department of Family Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang, Korea.
  • 4Department of Internal Medicine, Myongji Hospital, Goyang, Korea.
  • 5Office of Chief Executive Officer and Chairman, Department of General Surgery, Myongji Hospital, Goyang, Korea.
  • 6Department of Infectious Diseases, Myongji Hospital, Goyang, Korea.
  • 7CancerROP, Seoul, Korea. drjoseph@mjh.or.kr
  • 8Department of Pulmonary and Critical Care Medicine, Myongji Hospital, Goyang, Korea. baeckseung@gmail.com

Abstract

Since mid-December of 2019, coronavirus disease 2019 (COVID-19) infection has been spreading from Wuhan, China. The confirmed COVID-19 patients in South Korea are those who came from or visited China. As secondary transmissions have occurred and the speed of transmission is accelerating, there are rising concerns about community infections. The 54-year old male is the third patient diagnosed with COVID-19 infection in Korea. He is a worker for a clothing business and had mild respiratory symptoms and intermittent fever in the beginning of hospitalization, and pneumonia symptoms on chest computerized tomography scan on day 6 of admission. This patient caused one case of secondary transmission and three cases of tertiary transmission. Hereby, we report the clinical findings of the index patient who was the first to cause tertiary transmission outside China. Interestingly, after lopinavir/ritonavir (Kaletra, AbbVie) was administered, β-coronavirus viral loads significantly decreased and no or little coronavirus titers were observed.

Keyword

Coronavirus; COVID-19; Pneumonia; Tertiary Infection; Viral Load; Real-Time Reverse-Transcriptase Polymerase Chain Reaction

MeSH Terms

China
Clothing
Commerce
Coronavirus
Fever
Hospitalization
Humans
Korea*
Male
Pneumonia*
Thorax
Viral Load
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