Korean J Gastroenterol.  2019 Dec;74(6):356-361. 10.4166/kjg.2019.74.6.356.

Magnetic Resonance Imaging Findings of Biliary Adenofibroma

• Lee S
• Kim KW
• Jeong WK
• Yu E
• Jang KT

• KMID: 2469911
• DOI: http://doi.org/10.4166/kjg.2019.74.6.356

Abstract

Biliary adenofibroma is a rare tumor with a bile duct origin characterized by a complex tubulocystic non-mucin secreting biliary epithelium with abundant fibrous stroma. The MRI features of biliary adenofibroma are not well established. The authors encountered two patients with biliary adenofibroma and reviewed the literature focusing on the MRI findings. A well-circumscribed multicystic tumor with septal enhancement and no intrahepatic bile duct communication may be the characteristic MRI findings of biliary adenofibroma.

Keyword

Bile ducts; Adenofibroma; Magnetic resonance imaging

MeSH Terms

Adenofibroma*
Bile Ducts
Bile Ducts, Intrahepatic
Epithelium
Humans
Magnetic Resonance Imaging*

Figure

• 

  Fig. 1 A 63-year-old man with biliary adenofibroma (case 1). (A) Axial and (B) coronal T2-weighted images showed a bright signal intensity tumor with hypointense septa. (C) Axial unenhanced T1-weighted image showed a low signal intensity tumor with a lobulated border. After gadolinium administration, (D) axial delayed phase T1-weighted image showed septal enhancement.

• 

  Fig. 2 A 63-year-old man with a biliary adenofibroma (case 1). Gross specimen (A) showed a well-circumscribed multicystic tumor with thin fibrous septa delineating small cysts. (B) The tumor was composed of tubulo-glandular and microcystic structures embedded in the fibrous stroma (H&E, ×40). (C) The tubules and cysts were lined with cuboidal or low columnar biliary epithelial cells. The fibrous stroma contained spindle cells. No ovarian-like stroma was observed (H&E, ×400). (D) Positive immunostaining for α-smooth muscle actin (×100) was observed in the fibrous stroma.

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  Fig. 3 38-year-old man with biliary adenofibroma (case 2). (A) Axial and (B) coronal T2-weighted images showed a multilobulated and multiseptated cystic tumor. (C) Axial unenhanced T1-weighted image showed a tumor with low signal intensity. (D) Axial portal venous phase T1-weighted image showed septal and wall enhancement.

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  Fig. 4 38-year-old man with biliary adenofibroma (case 2). Gross specimen (A) showed an unencapsulated tumor with a solid and cystic appearance. (B) Tubulo-glandular structures with fibrous stroma characterized this tumor (H&E, ×40). (C) The tubules were lined with cuboidal or low columnar non-mucin secreting biliary epithelial cells (H&E, ×200).

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