Nucl Med Mol Imaging.  2019 Dec;53(6):432-435. 10.1007/s13139-019-00611-z.

Orbital IgG4 Disease: Imaging Findings on 68Ga-DOTANOC PET/CT

• Arora S
• Damle NA
• Meel R
• Sharma S
• Sen S
• Bal C
• Lata K
• Prakash S
• Yadav D
• Angamuthu

• KMID: 2469587
• DOI: http://doi.org/10.1007/s13139-019-00611-z

Abstract

Immunoglobulin G4 (IgG4)-related diseases are a spectrum of systemic inflammatory conditions of unknown etiology, which are characterized by infiltration of tissues by IgG4 plasma cells and sclerosing inflammation (Cheuk and Chan Adv Anat Pathol 17:303-32, 2010). Although this condition was initially described in relation to autoimmune pancreatitis, now it has been reported in almost every organ system of body (Zen and Nakanuma Am J Surg Pathol 34:1812-9, 2010, Masaki et al. Ann Rheuma Dis 68:1310-5, 2009). Orbital involvement by IgG4 disease can involve extraocular muscles (EOM), lacrimal glands, conjunctiva, eyelids, infraorbital nerve, orbital fat, and nasolacrimal system (McNab and McKelvie. Ophthal Plast Reconstr Surg 31:167-78, 2015, Katsura et al. Neuroradiology 54:873-82, 2012). The basis of using ⁶⁸Ga-DOTANOC PET/CT in IgG4 orbital disease is the known expression of somatostatin receptors in chronic inflammatory cells (Cuccurullo et al. Indian J Radiol Imaging 27:509-16, 2017) and also avidity shown previously in other IgG4-related diseases (Cheng et al. Clin Nucl Med 43:773-6, 2018).

Keyword

Orbital IgG4 disease; Somatostatin receptors; ⁶⁸Ga-DOTANOC PET/CT

MeSH Terms

Conjunctiva
Eyelids
Immunoglobulin G*
Immunoglobulins
Inflammation
Lacrimal Apparatus
Muscles
Orbit*
Orbital Diseases
Pancreatitis
Plasma Cells
Positron-Emission Tomography and Computed Tomography*
Receptors, Somatostatin
Immunoglobulin G
Immunoglobulins
Receptors, Somatostatin