Nucl Med Mol Imaging.  2015 Mar;49(1):57-60. 10.1007/s13139-014-0297-x.

Metastatic Neuroendocrine Tumour in a Renal Transplant Recipient: Dual-Tracer PET-CT with 18F-FDG and 68Ga-DOTANOC in This Rare Setting

• Karunanithi S
• Roy SG
• Sharma P
• Yadav R
• Bal C
• Kumar R

• KMID: 2313246
• DOI: http://doi.org/10.1007/s13139-014-0297-x

Abstract

Recipients of renal transplant are at increased risk of developing various malignancies, especially post-transplant lymphoproliferative disorder (PTLD) and skin cancers. Neuroendocrine tumours (NET) of the gastrointestinal tract have not been reported in this setting. Here we describe the case of a 75-year-old male who had undergone renal transplant 8 years back and now presented with significant weight loss and backache, clinically suspected as PTLD. 18F-Fluordeoxyglucose (18F-FDG) positron emission tomography-computed tomography (PET-CT) showed hypermetabolic lesions in the liver and rectum, raising the suspicion of PTLD. However, biopsy from the liver lesion showed poorly differentiated NET. 68Ga-labelled [1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid]-1-NaI3-octreotide (68Ga-DOTANOC) PET-CT was then done, which confirmed the primary lesion in the rectum with liver metastases.

Keyword

Neuroendocrine tumour; PET-CT; 68Ga-DOTANOC; 18F-FDG; Post-transplant lymphoproliferative disorder

MeSH Terms

Aged
Back Pain
Biopsy
Electrons
Fluorodeoxyglucose F18*
Gastrointestinal Tract
Humans
Liver
Lymphoproliferative Disorders
Male
Neoplasm Metastasis
Rectum
Skin Neoplasms
Transplantation*
Weight Loss
Fluorodeoxyglucose F18