Kidney Res Clin Pract.
2019 Dec;38(4):517-524. 10.23876/j.krcp.19.078.
Clinical features and outcomes in kidney transplant recipients with renal cell carcinoma: a single-center study
- Affiliations
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- 1Division of Nephrology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Rebublic of Korea. bch393@naver.com
- 2Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Rebublic of Korea.
- 3Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Rebublic of Korea.
- KMID: 2469382
- DOI: http://doi.org/10.23876/j.krcp.19.078
Abstract
- BACKGROUND
Previous studies have recommended a 2- to 5-year waiting time prior to kidney transplantation (KT) in patients with end-stage renal disease (ESRD) and symptomatic renal cell carcinoma (RCC) and no delay for incidental early-stage RCC. Data on Asian KT recipients are unavailable.
METHODS
This is a Korean single-center retrospective study on 35 KT recipients with ESRD and RCC. Patients were classified into two groups: early KT (KT performed within 1 year after nephrectomy for RCC, including KT with simultaneous nephrectomy) and delayed KT (KT performed over than 1 year after nephrectomy for RCC). Patient survival, graft survival, and cancer recurrence were compared between both groups.
RESULTS
There were no statistically significant differences in patient survival (P = 0.388), graft survival (P = 0.317), or graft rejection rate (P = 0.207) between the early and delayed KT groups. Additionally, there were no differences in pathological characteristics or RCC stage other than cancer histology: acquired cystic disease-associated RCC (47.4%) was the most common RCC type in the early KT group, whereas clear cell type (62.5%) was the most common RCC type in the delayed KT group. No RCC recurrence was observed.
CONCLUSION
Patients with early-stage and asymptomatic RCC do not require a mandatory observational period prior to KT after curative nephrectomy
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