Maxillofac Plast Reconstr Surg.  2019 ;41(1):11. 10.1186/s40902-019-0193-5.

Effect of bisphosphonate on temporomandibular joint in osteopenia-induced rats by botulinum toxin A injection on masticatory muscle: a preliminary study

• Kim JY
• Kim DH
• Jang HW
• Park KH
• Huh JK

• KMID: 2468959
• DOI: http://doi.org/10.1186/s40902-019-0193-5

Abstract

BACKGROUND
Botulinum toxin injection on the masticatory muscle induces the osteopenic condition on the ipsilateral condyle. Bisphosphonate suppresses bone resorption and is used to treat osteopenic or osteoporotic condition. This study aimed to evaluate the effect of bisphosphonate administration on prevention of condylar resorption and botulinum toxin A-induced disuse osteopenia in rats.
RESULTS
The volume of the condyle and bone volume/tissue volume (BV/TV, %) showed a strong tendency towards statistical significance (p ="‰0.052 and 0.058). Trabecular thickness (Tb.Th, mm) and trabecular number (Tb.N, 1/mm) were significantly smaller in the Botox group than in the other groups (p <"‰0.05). The volume of the condyle and BV/TV in the bisphosphonate 100 and bisphosphonate 200 groups showed similar values when compared with the control group.
CONCLUSION
Bisphosphonate administration after botulinum toxin A injection in the masticatory muscles appears to prevent condyle resorption and botulinum toxin-induced disuse osteopenia in rats.

Keyword

Bisphosphonate; Botulinum toxin; Mandibular condyle; Temporomandibular joint

MeSH Terms

Animals
Bone Diseases, Metabolic
Bone Resorption
Botulinum Toxins*
Mandibular Condyle
Masticatory Muscles*
Rats*
Temporomandibular Joint*
Botulinum Toxins