Clin Hypertens.  2019 ;25(1):12. 10.1186/s40885-019-0116-x.

Risk of hypertension in cancer patients treated with abiraterone: a meta-analysis

Affiliations
  • 1Division of Primary Care, State University of New York at Stony Brook, 205 North Belle Mead Road, East Setauket, Stony Brook, NY 11733 USA.
  • 2Division of Hematology and Oncology, Department of Medicine, School of Medicine, State University of New York at Stony Brook, 3 Edmund D. Pellegrino Rd, Stony Brook, NY 11794-9447 USA. shenhong.wu@stonybrookmedicine.edu
  • 3Division of Hematology and Oncology, Department of Medicine, Northport VA Medical Center, Northport, NY USA.

Abstract

BACKGROUND
Hypertension is one of the major side effects associated with abiraterone in the treatment of advanced prostate cancer. The specific contribution of abiraterone to hypertension has not been defined. We performed a systematic review and meta-analysis of randomized clinical trials to determine its overall risk.
METHODS
Databases including Pubmed (up to July 2018) and Google scholar (up to July 2018) were searched to identify relevant studies. Eligible studies were prospective randomized clinical trials with prostate cancer treated with abiraterone and prednisone. The incidence and relative risk (RR) of hypertension was calculated using random-effects or fixed-effects model depending on the heterogeneity of included studies.
RESULTS
A total of five studies including 5445 patients were selected for analysis. Among patients receiving abiraterone, the overall incidences of all grade and high grade (grade 3 and 4) were 21.9% (95% CI: 13.6-33.2%) and 10.2% % (95% CI: 6.9-11.6%). Abiraterone was associated with a significantly increased risk of hypertension of all grade with a relative risk of 1.80 (95% CI: 1.47-2.19%, p"‰<"‰0.001) and high grade with a relative risk of 2.11 (95%CI: 1.66-2.68%, p"‰<"‰0.001) in comparison with controls. The risk of hypertension may be affected by concurrent use of prednisone with 5"‰mg daily is associated with higher incidence than that of prednisone 5"‰mg twice daily (32.4% vs 16.5%).
CONCLUSION
There is a significant increase of developing hypertension in prostate cancer patients treated with abiraterone. Appropriate monitoring and management is strongly recommended to reduce the risk of cardiovascular events and treatment interruptions.

Keyword

Abiraterone; Prostate cancer; Hypertension; Adverse event; Risk

MeSH Terms

Humans
Hypertension*
Incidence
Population Characteristics
Prednisone
Prospective Studies
Prostatic Neoplasms
Prednisone
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