Korean J Radiol.  2017 Feb;18(1):94-106. 10.3348/kjr.2017.18.1.94.

Current Concepts in Non-Gastrointestinal Stromal Tumor Soft Tissue Sarcomas: A Primer for Radiologists

  • 1Department of Radiology, Tata Memorial Centre, Mumbai 400012, India. akshaybaheti@gmail.com
  • 2Department of Radiology, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • 3Department of Imaging, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  • 4Department of Radiology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.


Non-gastrointestinal stromal tumor (GIST) soft tissue sarcomas (STSs) are a heterogeneous group of neoplasms whose classification and management continues to evolve with better understanding of their biologic behavior. The 2013 World Health Organization (WHO) has revised their classification based on new immunohistochemical and cytogenetic data. In this article, we will provide a brief overview of the revised WHO classification of soft tissue tumors, discuss in detail the radiology and management of the two most common adult non-GIST STS, namely liposarcoma and leiomyosarcoma, and review some of the emerging histology-driven targeted therapies in non-GIST STS, focusing on the role of the radiologist.


Soft tissue sarcomas; World Health Organization classification; Liposarcoma; Leiomyosarcoma

MeSH Terms

Leiomyosarcoma/classification/diagnostic imaging/genetics
Liposarcoma/classification/diagnostic imaging/genetics
Sarcoma/classification/*diagnostic imaging/genetics
Soft Tissue Neoplasms/classification/*diagnostic imaging/genetics
Tomography, X-Ray Computed
World Health Organization
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