Korean J Radiol.  2017 Feb;18(1):54-70. 10.3348/kjr.2017.18.1.54.

Diffuse Large B-Cell Lymphoma in the Era of Precision Oncology: How Imaging Is Helpful

  • 1Department of Imaging, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA. akeraliya@partners.org
  • 2Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • 3Department of Nuclear Medicine and PET/CT, Jaslok Hospital and Research Centre, Mumbai 400026, India.


Diffuse large B cell lymphoma (DLBCL) is the most common histological subtype of Non-Hodgkin's lymphoma. As treatments continues to evolve, so do imaging strategies, and positron emission tomography (PET) has emerged as the most important imaging tool to guide oncologists in the diagnosis, staging, response assessment, relapse/recurrence detection,and therapeutic decision making of DLBCL. Other imaging modalities including magnetic resonance imaging (MRI), computed tomography (CT), ultrasound, and conventional radiography are also used in the evaluation of lymphoma. MRI is useful for nervous system and musculoskeletal system involvement and is emerging as a radiation free alternative to PET/CT. This article provides a comprehensive review of both the functional and morphological imaging modalities, available in the management of DLBCL.


Lymphoma; Diffuse large B cell lymphoma; FDG-positron emission tomography/CT; MRI

MeSH Terms

Lymphoma, Large B-Cell, Diffuse/*diagnostic imaging/pathology/therapy
Magnetic Resonance Imaging/methods
Multimodal Imaging/methods
Neoplasm Recurrence, Local
Positron Emission Tomography Computed Tomography/methods
Positron-Emission Tomography/methods
Precision Medicine/methods
Tomography, X-Ray Computed/methods
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