Yonsei Med J.  2020 Jan;61(1):15-19. 10.3349/ymj.2020.61.1.15.

Increased Progastrin-Releasing Peptide Expression is Associated with Progression in Gastric Cancer Patients

Affiliations
  • 1Department of Clinical Laboratory, Binhai County People's Hospital, Jiangsu, China. lili5898@126.com
  • 2Department of Medical Oncology, Binhai County People's Hospital, Jiangsu, China.
  • 3Department of Gastroenterology, Binhai County People's Hospital, Jiangsu, China.
  • 4Department of Clinical Laboratory, Binhai County Second Hospital, Jiangsu, China.

Abstract

PURPOSE
The purpose of this study was to assess the diagnostic and prognostic value of serum progastrin-releasing peptide (ProGRP) in patients with gastric cancer (GC).
MATERIALS AND METHODS
A total of 150 patients with GC (89 males and 61 females) were recruited, including those with stage I (n=28), stage II (n=33), stage III (n=50), and stage IV (n=39) disease; 50 healthy controls and 66 patients with benign gastric diseases were also enrolled. Levels of serum ProGRP, carcinoembryonic antigen (CEA), and carbohydrate antigen 72-4 (CA72-4) were measured in all subjects.
RESULTS
Serum ProGRP levels were significantly higher in GC patients than in controls (p<0.001), and ProGRP was significantly correlated with tumor size, tumor node metastasis stage, differentiation, invasion depth, and lymph node metastasis (p< 0.005). ProGRP levels were significantly decreased after chemotherapy (p<0.001). Receiver operating characteristic curves revealed a sensitivity and specificity for serum ProGRP in GC of 85.9% and 81.2%, respectively. ProGRP levels were positively correlated with CA72-4 and CEA (r=0.792 and 0.688, p<0.05, respectively). Combined detection of ProGRP, CEA, and CA72-4 showed the best diagnostic power for GC.
CONCLUSION
ProGRP may be useful as a potential biomarker for GC diagnosis and therapy.

Keyword

Progastrin-releasing peptide; gastric cancer; progression

MeSH Terms

Carcinoembryonic Antigen
Diagnosis
Drug Therapy
Humans
Lymph Nodes
Male
Neoplasm Metastasis
ROC Curve
Sensitivity and Specificity
Stomach Diseases
Stomach Neoplasms*
Carcinoembryonic Antigen

Figure

  • Fig. 1 Comparison of serum progastrin-releasing peptide (ProGRP) levels in patients with gastric cancer (GC), patients with benign gastric disease, and healthy controls.

  • Fig. 2 Receiver operating characteristic (ROC) curve for serum progastrin-releasing peptide levels in patients with gastric cancer.

  • Fig. 3 Serum progastrin-releasing peptide (ProGRP) levels positively correlated with carcinoembryonic antigen (CEA) (A) and carbohydrate antigen 72-4 (CA72-4) (B), respectively, in patients with gastric cancer.


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