Cardiovasc Imaging Asia.
2019 Jan;3(1):1-7. 10.22468/cvia.2018.00213.
Dynamic Coronary 320-Row CT Angiography Using Low-Dose Contrast and Temporal Maximum Intensity Projection: A Comparison with Standard Coronary CT Angiography
- Affiliations
-
- 1Division of Radiology, Department of Medical Technology, Kyushu University Hospital, Fukuoka, Japan. tukasa@r-tec.med.kyushu-u.ac.jp
- 2Department of Molecular Imaging & Diagnosis, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
- 3Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
- 4Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
- 5Department of Clinical Application, Ziosoft Inc., Tokyo, Japan.
- 6Department of Diagnostic Imaging and Nuclear Medicine, Tokyo Women's Medical University, Tokyo, Japan.
- KMID: 2465775
- DOI: http://doi.org/10.22468/cvia.2018.00213
Abstract
OBJECTIVE
The smallest diagnostically sufficient amount of contrast media (CM) should be used for coronary computed tomography angiography (CCTA) to minimize the risk of contrast-induced nephrotoxicity in elderly patients with coronary artery disease. The purpose of this study was to propose dynamic-CCTA using a low dose of CM and temporal maximum intensity projection (TMIP) and to investigate its image quality compared to standard-CCTA.
MATERIALS AND METHODS
Participants comprised 30 patients with coronary artery disease who underwent dynamic-CCTA and standard-CCTA using 320-row CT. Dynamic-CCTA was continuously performed at mid-diastole throughout 15-25 cardiac cycles after bolus injection of CM [103 mg iodine/kg body weight (mgI/kg)]. TMIP-CCTA was reconstructed from three-phase dynamic-CCTA data, including a phase with peak enhancement of the ascending aorta. Standard-CCTA was performed using a standard CM dose (259 mgI/kg). Image quality of both TMIP-CCTA and standard-CCTA was analyzed.
RESULTS
The amount of CM used in TMIP-CCTA and standard-CCTA was 16.2±2.6 mL and 40.1±7.3 mL, respectively. The mean effective radiation dose was not significantly different between the two methods. Mean coronary attenuation was significantly lower for TMIP-CCTA than standard-CCTA [346.9±82.8 Hounsfield units (HU) vs. 455.4±75.3 HU, p<0.05]. Image noise was significantly lower for TMIP-CCTA than standard-CCTA (20.0±3.2 HU vs. 28.1±3.6 HU, p<0.05). There were no differences in signal-to-noise ratio and visual assessment scores between the two methods.
CONCLUSION
TMIP-CCTA can be performed using more than 50% less CM with the same image quality as standard-CCTA.
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