Anesth Pain Med.  2019 Oct;14(4):407-411. 10.17085/apm.2019.14.4.407.

Accuracy assessment of a PION TCI pump based on international standards

• Doh I
• Lee SH
• Lee YH
• Jeon B
• Choi BM
• Noh GJ

• KMID: 2465337
• DOI: http://doi.org/10.17085/apm.2019.14.4.407

Abstract

BACKGROUND
Inaccuracies associated with target-controlled infusion (TCI) delivery systems are attributable to both software and hardware issues, as well as pharmacokinetic variability. However, little is known about the inaccuracy of the syringe pump operating in TCI mode. This study aimed to evaluate the accuracy of the TCI pump based on international standards.
METHODS
A test apparatus for accuracy evaluation of a syringe pump (PION TCI®, Bionet Co. Ltd.) was designed to apply the gravimetric method. Pump accuracy was evaluated in terms of deviation defined by the following equation: infusion rate deviation (%) = (Rate(mea) − Rate(est)) / Rate(est) × 100, where Rate(mea) is the infusion rate (ml/h) as measured by the gravimetric system, and Rate(est) is the infusion rate (ml/h) as estimated by the pump. An infusion rate representing TCI mode was determined from previous clinical trial data which evaluated the predictive performance of the pharmacokinetic model. The PION TCI pump used in that clinical trial was used to evaluate accuracy of the syringe pump. The distribution of infusion rates obtained from the clinical trial was calculated, and the median value of the distribution was determined as the representative value.
RESULTS
The representative infusion rate representing TCI mode was 31 ml/h, at which the infusion rate deviation was 4.5 ± 1.6%.
CONCLUSIONS
The inaccuracy of the syringe pump contributing to TCI system inaccuracy is insignificant.

Keyword

Accuracy; Infusion; Pump

MeSH Terms

Mesons*
Methods
Syringes

Figure

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  Fig. 1 Experimental setup for accuracy evaluation of the PION TCI pump. PC: personal computer, TCI: targetcontrolled infusion.

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  Fig. 2 Frequency distribution of infusion rates during propofol administration using a PION TCI pump from the induction of anesthesia to the time of the last blood sampling. The vertical red dotted line shows median frequency. TCI: target-controlled infusion.

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