Cancer Res Treat.  2019 Apr;51(2):556-567. 10.4143/crt.2018.221.

Health-Related Quality of Life Changes in Prostate Cancer Patients after Radical Prostatectomy: A Longitudinal Cohort Study

  • 1Department of Family Medicine, Samsung Medical Center, Seoul, Korea.
  • 2Department of Digital Health, SAIHST, Sungkyunkwan University, Seoul, Korea.
  • 3Department of Urology, Kyung Hee University School of Medicine, Seoul, Korea.
  • 4Department of Urology, School of Medicine, Kyungpook National University, Daegu, Korea.
  • 5Department of Urology, Chungbuk National University College of Medicine, Cheongju, Korea.
  • 6Department of Urology, Pusan National University Yangsan Hospital, Yangsan, Korea.
  • 7Department of Urology, Wonkwang University School of Medicine, Iksan, Korea.
  • 8Department of Urology, Chonnam National University Medical School, Gwangju, Korea.
  • 9College of Medicine/Graduate School of Health Science Business Convergence, Chungbuk National University, Cheongju, Korea.
  • 10Division of Cancer Policy and Management, National Cancer Control Research Institute, National Cancer Center, Goyang, Korea.
  • 11Department of Urology, Eulji University Hospital, Eulji University School of Medicine, Daejeon, Korea.


Health-related quality of life (HRQOL) information related to radical prostatectomy (RP) is valuable for prostate cancer (PC) patients needing to make treatment decisions. We aimed to investigate HRQOL change in PC patients who underwent three types of RP (open, laparoscopic, or robotic) and compared their HRQOL with that of general population.
Patients were prospectively recruited between October 2014 and December 2015. European Organization for Research and Treatment of Cancer Quality-of-Life Questionnaire (EORTC QLQ-C30) and PC-specific module (PR25) were administered before surgery (baseline) and at postoperative 3 and 12 months. At each time point, HRQOL was compared, and a difference of 10 out of 0-100 scale was considered clinically significant.
Among 258 screened patients, 209 (41 open, 63 laparoscopic, and 105 robotic surgeries) were included. Compared to baseline, physical, emotional, and cognitive functioning improved at 12 months. Role functioning worsened at 3 months, but recovered to baseline at 12 months. Pain, insomnia, diarrhea, and financial difficulties also significantly improved at 12 months. Most PR25 scales excluding bowel symptoms deteriorated at 3 months. Urinary symptoms and incontinence aid recovered at 12 months, whereas sexual activity and sexual function remained poor at 12 months. Clinically meaningful differences in HRQOL were not observed according to RP modalities. Compared to the general population, physical and role functioning were significantly lower at 3 months, but recovered by 12 months. Social functioning did not recover.
Most HRQOL domains showed recovery within 12 months after RP, excluding sexual functioning and social functioning. Our findings may guide patients considering surgical treatment for PC.


Health-related quality of life; Prostate neoplasms; Radical prostatectomy; Social function

MeSH Terms

Cohort Studies*
Prospective Studies
Prostatic Neoplasms*
Quality of Life*
Sexual Behavior
Sleep Initiation and Maintenance Disorders
Weights and Measures
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