J Korean Orthop Assoc.  1971 Sep;6(3):283-289. 10.4055/jkoa.1971.6.3.283.

Hand-Schuller-Christian Disease

• Kim HS
• Yune SH

• KMID: 2464011
• DOI: http://doi.org/10.4055/jkoa.1971.6.3.283

Abstract

In 1953, Lichtenstein suggested to use "Histiocytosis X" as an unifying diagnostic term to represent Eosinophilic granuloma, Hand-Schiiller-Christian disease, and Letterer-Siwe disease. The author experienced a case of Hand-Schuller-Christian disease in six year old girl. She has been treated under the diagnosis of Calves disease. But later, it was confirmed as Hand-Schiiller-Christian disease by clinically and pathologically, involving multiple region of entire skeletal system, but sparing the musculocutaneous and nervous system. Clinically, anemia, malaise, high fever and hepatomegaly were present. Co60 isotope irradiation combined with antibiotics was done for 87 days twice weekly in a dose of 50 R at a time. At the time of discharge clinical symptoms were subsided. In X-Ray check, one year after treatment, bony defects were consolidated with new bone and the result was successful.

MeSH Terms

Anemia
Anti-Bacterial Agents
Diagnosis
Eosinophilic Granuloma
Female
Fever
Hepatomegaly
Histiocytosis, Langerhans-Cell
Humans
Nervous System
Anti-Bacterial Agents