J Liver Cancer.  2019 Sep;19(2):85-90. 10.17998/jlc.19.2.85..

Liver Transplantation in Mixed Hepatocellular Carcinoma and Cholangiocarcinoma

• Kim JM

• KMID: 2463608
• DOI: http://doi.org/10.17998/jlc.19.2.85.

Abstract

Mixed hepatocellular carcinoma and cholangiocarcinoma (HCC-CC) are rare tumors, and the risk factors associated with them are not well understood yet. Moreover, the diagnosis of mixed HCC-CC can be complicated due to the difficulty in distinguishing mixed HCC-CC from HCC and intrahepatic CCC on radiological images. Serum tumor markers are useful when the radiological images are inconclusive. It remains unclear whether the prognosis of mixed HCC-CC differs from that of HCC. However, several studies have reported that the tumor recurrence and patient survival rates of mixed HCC-CC were similar to those of HCC after liver transplantation (LT) and liver resection. In this paper, we report that LT in patients with mixed HCC-CC achieves outcomes which are similar to those seen in LT for HCC. Therefore, the diagnosis of mixed HCC-CC should not be considered as a contraindication for LT.

Keyword

Liver transplantation; Liver malignancy; Outcomes

MeSH Terms

Biomarkers, Tumor
Carcinoma, Hepatocellular*
Cholangiocarcinoma*
Diagnosis
Humans
Liver Transplantation*
Liver*
Prognosis
Recurrence
Risk Factors
Survival Rate
Biomarkers, Tumor

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