J Korean Radiol Soc.  1981 Jun;17(1):1-13. 10.3348/jkrs.1981.17.1.1.

An experimental study on effect of tourniquet ischemia and hyperthermia on irradiation

• Park JH
• Han MC

• KMID: 2463414
• DOI: http://doi.org/10.3348/jkrs.1981.17.1.1

Abstract

To evaluate the influence of tourniquet ischemia and hyperthermia on the radiation effect of skin, theexperimental study was undertaken using a total of 344 mice. A single dose of irradiation from 2000 rads to 8000rads was delivered on skin of mouse tail after hyperthermia of 40degrees(C) to 42degrees(C) with or withouttourniquet application in various subgroups. The resuls are summarized as follows; 1. Tourniquet ischemia duringirradiation caused radioprotective effect. 2. Hyperthermia before irradiation induced radiosensitizing effect,which was increased with temperature elevation of hyperthermia. 3. In combination of tourniquet ischemia andhyperthermia, evident radiosensitizing effect waas noticed. This enhancing effect on irradiation was greater thanthe effect i hyperthermia only. It could be suggested that the combination of tourniquet application andhyperthermia might be intorduced in clinical radiotherapy after trail of clinical experiments on applicable typeand sutiable location of tumors.

MeSH Terms

Animals
Fever*
Ischemia*
Mice
Radiation Effects
Radiation-Sensitizing Agents
Radiotherapy
Skin
Tail
Tourniquets*
Radiation-Sensitizing Agents