J Korean Radiol Soc.  1983 Mar;19(1):176-182. 10.3348/jkrs.1983.19.1.176.

99mTc-MDP bone imaging in Legg-Calve-Perthes disease

• Nam KJ
• Lee SW
• Kim EK
• Kim SY

• KMID: 2463219
• DOI: http://doi.org/10.3348/jkrs.1983.19.1.176

Abstract

The pathology of Legg-Calve-Perthes disease be can described as a vascular distrubance leading to necrosis andsubsequent revascularization of the femoral epiphyseal ossification center. The regional distribution ofbone-seeking radiopharmaceuticals in the skeleton can depend on a number of factors, but bone blood flow is amajor phsiological determinant of regional skeletal uptake of Tc-99m polyphosphate and bone imaging may thus beused for the detection of areas with both decreased and increased vascular supply. The authors analyzed thescintigraphic findings of 14 cases of Legg-Calve-Perthes disease at Kyung Hee University Hospital from Mar, '81 toOct. '82. The resuls were as follows; 1. Scintigraphy revealed area of absent radioactivity in 14 cases; lateral2/3 portion of the femoral epiphyseal ossification center was involved in 9 cases among 14 cases, and alsoincreased radioactivity in epiphyseal ossification center, epiphyseal plate, or poximal metaphysis of femur wereassociated in 7 cases. 2. Three cases had radiographically normal hip, whereas scintigraphy revealed distinctlyabsent radioactivity in femoral epiphyseal ossification center. 3. Magnification of hip imaging using a pinholecollimator provided good definition of presence and extent of pathologic defect or uptake in epiphysealossification center, epiphyseal plate, and metaphysis. Bone imaging provided earlier and more accurate informationconcering the extent of the necrotic and revascularization process of Legg-Calv-Perthes disease than theradiographs alone.

MeSH Terms

Femur
Growth Plate
Hip
Legg-Calve-Perthes Disease*
Necrosis
Pathology
Radioactivity
Radionuclide Imaging
Radiopharmaceuticals
Skeleton
Technetium Tc 99m Medronate*
Radiopharmaceuticals
Technetium Tc 99m Medronate