J Korean Soc Endocrinol.  1995 Dec;10(4):456-466.

A Korean Pedigree of Paget Bone Disease: Including a Case of Panostotic Paget Bone Disease complicated with Giant Cell Reparative Granuloma

Abstract

The polyglandular autoimmune syndrome designates the dysfunction of endocrine and nonendocrine system involving two or more organs on the basis of an autoimmune mechanism. The autoimmune nature of these diseases has been based on the presence of lymphocytic infiltration in the affected gland, organ specific autoantibodies in the serum, cellular immune defects and an association with the HLA DR/DQ genes or immune response genes. This syndrome is usually classified into three classes and their etiology or pathogenesis is still not completely understood. A 28-year-old woman developed vitiligo and insulin dependent diabetes mellitus during the treatment of Graves' disease with antithyroid drug. She had a tendency of spontaneous ketonemia and serum c-peptide levels were low(0.21, 0.16ng/mL: fasting and glucagon stimulated). Thyrotrophin binding inhibitor immunoglobulin and pancreas iIslet cell cytoplasmic antibody were positive. We report here a case of polyglandular autoimmune syndrome, type III manifesting Graves' disease, vitiligo, and insulin dependent diabetes mellitus.


MeSH Terms

Adult
Autoantibodies
Bone Diseases*
C-Peptide
Cytoplasm
Diabetes Mellitus
Fasting
Female
Genes, MHC Class II
Giant Cells*
Glucagon
Granuloma*
Graves Disease
Humans
Immunoglobulins
Insulin
Ketosis
Pancreas
Pedigree*
Thyrotropin
Vitiligo
Autoantibodies
C-Peptide
Glucagon
Immunoglobulins
Insulin
Thyrotropin
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