J Adv Prosthodont.  2019 Oct;11(5):247-252. 10.4047/jap.2019.11.5.247.

The effect of periodontal and prosthodontic therapy on glycemic control in patients with diabetes

Affiliations
  • 1Department of Periodontology, Kyungpook National University School of Dentistry, Daegu, Republic of Korea. leejm@knu.ca.kr
  • 2Department of Prosthodontics, Kyungpook National University School of Dentistry, Daegu, Republic of Korea.
  • 3College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, Republic of Korea. sangkyu@knu.ac.kr

Abstract

PURPOSE
To evaluate the effect of periodontal and prosthodontic therapy on glycated hemoglobin A(HbA1c) level in patients with diabetes.
MATERIALS AND METHODS
This is a retrospective study of 70 patients suffering from diabetes who visited the Kyungpook National University Hospital between January 2016 and May 2018. Patients underwent medical evaluation for their routine check-up, which includes laboratory test for HbA1c levels. Among the 70 patients, 35 patients also visited Kyungpook National University Dental Hospital during the same period to receive periodontal and prosthodontic therapy, while the other 35 patients did not receive such therapy. The HbA1c levels were compared before and after periodontal and prosthodontic therapy. Comparisons between groups and within groups were performed using independent t-test.
RESULTS
The HbA1c levels in the group who have received periodontal and prosthodontic therapy decreased from 7.2 to 6.7 (P=.001). The HbA1c levels in the control group decreased from 7.2 to 7.1 (P=.580). The difference in changes between the two patient groups was statistically significant (P=.011).
CONCLUSION
Periodontal and prosthodontic therapy can be effective on glycemic control in patients with diabetes.

Keyword

Diabetes mellitus; Glycated hemoglobin A; Periodontal diseases; Prosthodontics

MeSH Terms

Diabetes Mellitus
Gyeongsangbuk-do
Hemoglobin A, Glycosylated
Humans
Periodontal Diseases
Prosthodontics
Retrospective Studies

Figure

  • Fig. 1 Comparison of HbA1c reduction between treatment and control group before and after therapy.

  • Fig. 2 Comparison of HbA1c reduction between active and supportive periodontal group before and after therapy.

  • Fig. 3 Comparison of HbA1c reduction between periodontal with prosthodontic and periodontal without prosthodontic group before and after therapy.

  • Fig. 4 Simple linear regression analysis showing the correlation between level of HbA1c before therapy and the number of teeth lost.


Reference

1. Sonnenschein SK, Meyle J. Local inflammatory reactions in patients with diabetes and periodontitis. Periodontol 2000. 2015; 69:221–254. PMID: 26252411.
Article
2. Mealey B. Diabetes and periodontal diseases. J Periodontol. 1999; 70:935–949.
3. Xie W, Du L. Diabetes is an inflammatory disease: evidence from traditional Chinese medicines. Diabetes Obes Metab. 2011; 13:289–301. PMID: 21205111.
Article
4. Taiyeb-Ali TB, Raman RP, Vaithilingam RD. Relationship between periodontal disease and diabetes mellitus: an Asian perspective. Periodontol 2000. 2011; 56:258–268. PMID: 21501247.
Article
5. Chávarry NG, Vettore MV, Sansone C, Sheiham A. The relationship between diabetes mellitus and destructive periodontal disease: a meta-analysis. Oral Health Prev Dent. 2009; 7:107–127. PMID: 19583037.
6. Lalla E, Papapanou PN. Diabetes mellitus and periodontitis: a tale of two common interrelated diseases. Nat Rev Endocrinol. 2011; 7:738–748. PMID: 21709707.
Article
7. Emrich LJ, Shlossman M, Genco RJ. Periodontal disease in non-insulin-dependent diabetes mellitus. J Periodontol. 1991; 62:123–131. PMID: 2027060.
Article
8. Lalla E, Cheng B, Lal S, Tucker S, Greenberg E, Goland R, Lamster IB. Periodontal changes in children and adolescents with diabetes: a case-control study. Diabetes Care. 2006; 29:295–299. PMID: 16443876.
9. Taylor GW, Burt BA, Becker MP, Genco RJ, Shlossman M, Knowler WC, Pettitt DJ. Non-insulin dependent diabetes mellitus and alveolar bone loss progression over 2 years. J Periodontol. 1998; 69:76–83. PMID: 9527565.
Article
10. Borgnakke WS, Ylöstalo PV, Taylor GW, Genco RJ. Effect of periodontal disease on diabetes: systematic review of epidemiologic observational evidence. J Clin Periodontol. 2013; 40:S135–S152. PMID: 23627324.
Article
11. Barros SP, Williams R, Offenbacher S, Morelli T. Gingival crevicular fluid as a source of biomarkers for periodontitis. Periodontol 2000. 2016; 70:53–64. PMID: 26662482.
Article
12. Salvi GE, Yalda B, Collins JG, Jones BH, Smith FW, Arnold RR, Offenbacher S. Inflammatory mediator response as a potential risk marker for periodontal diseases in insulin-dependent diabetes mellitus patients. J Periodontol. 1997; 68:127–135. PMID: 9058329.
Article
13. Wu T, Trevisan M, Genco RJ, Falkner KL, Dorn JP, Sempos CT. Examination of the relation between periodontal health status and cardiovascular risk factors: serum total and high density lipoprotein cholesterol, C-reactive protein, and plasma fibrinogen. Am J Epidemiol. 2000; 151:273–282. PMID: 10670552.
Article
14. Naguib G, Al-Mashat H, Desta T, Graves DT. Diabetes prolongs the inflammatory response to a bacterial stimulus through cytokine dysregulation. J Invest Dermatol. 2004; 123:87–92. PMID: 15191547.
Article
15. Noack B, Genco RJ, Trevisan M, Grossi S, Zambon JJ, De Nardin E. Periodontal infections contribute to elevated systemic C-reactive protein level. J Periodontol. 2001; 72:1221–1227. PMID: 11577954.
Article
16. Loos BG, Craandijk J, Hoek FJ, Wertheim-van Dillen PM, van der Velden U. Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients. J Periodontol. 2000; 71:1528–1534. PMID: 11063384.
Article
17. Mealey BL, Oates TW. American Academy of Periodontology. Diabetes mellitus and periodontal diseases. J Periodontol. 2006; 77:1289–1303. PMID: 16881798.
Article
18. Stewart JE, Wager KA, Friedlander AH, Zadeh HH. The effect of periodontal treatment on glycemic control in patients with type 2 diabetes mellitus. J Clin Periodontol. 2001; 28:306–310. PMID: 11314885.
Article
19. Li Q, Hao S, Fang J, Xie J, Kong XH, Yang JX. Effect of non-surgical periodontal treatment on glycemic control of patients with diabetes: a meta-analysis of randomized controlled trials. Trials. 2015; 16:291. PMID: 26137892.
Article
20. Teshome A, Yitayeh A. The effect of periodontal therapy on glycemic control and fasting plasma glucose level in type 2 diabetic patients: systematic review and meta-analysis. BMC Oral Health. 2016; 17:31. PMID: 27473177.
Article
21. Mauri-Obradors E, Merlos A, Estrugo-Devesa A, Jané-Salas E, López-López J, Viñas M. Benefits of non-surgical periodontal treatment in patients with type 2 diabetes mellitus and chronic periodontitis: A randomized controlled trial. J Clin Periodontol. 2018; 45:345–353. PMID: 29265454.
Article
22. Sanz M, Ceriello A, Buysschaert M, Chapple I, Demmer RT, Graziani F, Herrera D, Jepsen S, Lione L, Madianos P, Mathur M, Montanya E, Shapira L, Tonetti M, Vegh D. Scientific evidence on the links between periodontal diseases and diabetes: Consensus report and guidelines of the joint workshop on periodontal diseases and diabetes by the International Diabetes Federation and the European Federation of Periodontology. J Clin Periodontol. 2018; 45:138–149. PMID: 29280174.
Article
23. Pretzl B, Kaltschmitt J, Kim TS, Reitmeir P, Eickholz P. Tooth loss after active periodontal therapy. 2: tooth-related factors. J Clin Periodontol. 2008; 35:175–182. PMID: 18199151.
Article
24. Madianos PN, Koromantzos PA. An update of the evidence on the potential impact of periodontal therapy on diabetes outcomes. J Clin Periodontol. 2018; 45:188–195. PMID: 29277978.
Article
25. Mauri-Obradors E, Jané-Salas E, Sabater-Recolons Mdel M, Vinas M, López-López J. Effect of nonsurgical periodontal treatment on glycosylated hemoglobin in diabetic patients: a systematic review. Odontology. 2015; 103:301–313. PMID: 25062756.
Article
26. Wang TF, Jen IA, Chou C, Lei YP. Effects of periodontal therapy on metabolic control in patients with type 2 diabetes mellitus and periodontal disease: a meta-analysis. Medicine (Baltimore). 2014; 93:e292. PMID: 25526470.
27. Moeintaghavi A, Arab HR, Bozorgnia Y, Kianoush K, Alizadeh M. Non-surgical periodontal therapy affects metabolic control in diabetics: a randomized controlled clinical trial. Aust Dent J. 2012; 57:31–37. PMID: 22369555.
Article
28. Sun WL, Chen LL, Zhang SZ, Wu YM, Ren YZ, Qin GM. Inflammatory cytokines, adiponectin, insulin resistance and metabolic control after periodontal intervention in patients with type 2 diabetes and chronic periodontitis. Intern Med. 2011; 50:1569–1574. PMID: 21804283.
Article
29. Iwamoto Y, Nishimura F, Nakagawa M, Sugimoto H, Shikata K, Makino H, Fukuda T, Tsuji T, Iwamoto M, Murayama Y. The effect of antimicrobial periodontal treatment on circulating tumor necrosis factor-alpha and glycated hemoglobin level in patients with type 2 diabetes. J Periodontol. 2001; 72:774–778. PMID: 11453240.
Article
30. Matsuda Y, Minagawa T, Okui T, Yamazaki K. Resveratrol suppresses the alveolar bone resorption induced by artificial trauma from occlusion in mice. Oral Dis. 2018; 24:412–421. PMID: 28944599.
Article
31. Müller S, Eickholz P, Reitmeir P, Eger T. Long-term tooth loss in periodontally compromised but treated patients according to the type of prosthodontic treatment. A retrospective study. J Oral Rehabil. 2013; 40:358–367. PMID: 23362962.
Article
32. Polak D, Shapira L. An update on the evidence for pathogenic mechanisms that may link periodontitis and diabetes. J Clin Periodontol. 2018; 45:150–166. PMID: 29280184.
Article
Full Text Links
  • JAP
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr