J Periodontal Implant Sci.  2013 Apr;43(2):79-86.

Effect of scaling and root planing combined with systemic doxycycline therapy on glycemic control in diabetes mellitus subjects with chronic generalized periodontitis: a clinical study

• Gaikwad SP
• Gurav AN
• Shete AR
• Desarda HM

Abstract

PURPOSE
The purpose of study was to compare glycemic control using glycated hemoglobin levels (HbA1c) in diabetic patients with chronic generalized periodontitis (CGP) undergoing scaling and root planing (SRP) with and without systemic doxycycline.
METHODS
Fifty subjects with type 2 diabetes mellitus (T2DM) and CGP receiving antidiabetic therapy were selected for study. The selected subjects were randomly assigned to two groups (test group [TG] and control group [CG]) comprising 25 patients each. The TG received SRP followed by systemic doxycycline. The CG received treatment with SRP only. The periodontal parameters were recorded at baseline (day zero), and every 1 month for 4 months and included probing depth, clinical attachment level, plaque index, gingival index, and HbA1c level were recorded at baseline (day zero) and at the end of 4 months.
RESULTS
A statistically significant effect was demonstrated for the periodontal parameters for both the TG and CG. HbA1c values did not show a statistically significant difference in the treatment group as compared to the CG.
CONCLUSIONS
The authors concluded that nonsurgical periodontal therapy improved glycemic control in patients with T2DM in both groups, but no statistical difference was observed with adjunctive systemic doxycycline therapy. A further study with a larger sample size is required.

Keyword

Chronic periodontitis; Diabetes mellitus; Glycosylated hemoglobin A; Periodontal debridement

MeSH Terms

Chronic Periodontitis
Diabetes Mellitus
Diabetes Mellitus, Type 2
Doxycycline
Hemoglobin A, Glycosylated
Hemoglobins
Humans
Periodontal Debridement
Periodontal Index
Periodontitis
Root Planing
Sample Size
Doxycycline
Hemoglobin A, Glycosylated
Hemoglobins

Figure

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  Figure 1 Comparative evaluation of glycated hemoglobin (HbA1c) levels in the test and control groups.

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  Figure 2 Comparative evaluation of probing depth (PD) in the test and control groups.

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  Figure 3 Comparative evaluation of clinical attachment level (CAL) in the test and control groups.

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  Figure 4 Comparative evaluation of the plaque index (PI) in the test and control groups.

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  Figure 5 Comparative evaluation of gingival index (GI) in the test and control groups.

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