J Korean Soc Endocrinol.  1994 Jun;10(2):125-130.

Amyloid Goiter

Abstract

Amyloidosis is a systemic disorder of unknown etiology, The pathophysiological precess is caused by deposition of amyloid fibrils in tissues of the body. Almost any organ in the body can be affected, but amyloid goiter is a very rare presentation.A definitive diagnosis of amyloidosis requires tissue examination using special stains and electron microscopy. We had recently experienced a case of 62 year-old man who was found to have amyloid goiter after thyroid surgery.The patient was admitted Keimyung University Medical Center for evaluation of rapid growing thyroid mass and lobectomy of right thyroid gland was performed.The light microscopic finding showed eosinophilic hyalinized stroma containing one thick-walled blood wessel in the hematoxyline and eosin stain. Congo-red stain on polarized light showed apple-green birefringence of amyloid in thyroid and abdominal fat tissues. Using the PAP method, nodular deposits of amyloid in the stroma and blood vessels are stained positively with anti-AA serum. Electron microscopic finding showed randomly arranged and nonbranching fibrillary rods in the stroma.


MeSH Terms

Abdominal Fat
Academic Medical Centers
Amyloid*
Amyloidosis
Birefringence
Blood Vessels
Coloring Agents
Diagnosis
Eosine Yellowish-(YS)
Eosinophils
Goiter*
Hematoxylin
Humans
Hyalin
Methods
Microscopy, Electron
Thyroid Gland
Amyloid
Coloring Agents
Eosine Yellowish-(YS)
Hematoxylin
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