J Korean Orthop Assoc.  1976 Mar;11(1):110-115. 10.4055/jkoa.1976.11.1.110.

The Effect of Intra-articular Injection of Steroid on Lysozyme Activity in Patient with Rheumatoid Arthritis

• Lee JY
• Kim BH

• KMID: 2461359
• DOI: http://doi.org/10.4055/jkoa.1976.11.1.110

Abstract

The lysozyme activities of knee joint fluid in normal Korean people, patients with rheumatoid arthritis, and patients with degenerative arthritis have been reported by Lee in 1974. This time I have studied the chronologic changes of lysozyme activity of knee joint fluid in patients with rheumatoid arthritis following intra-articular injection of steroid preparation (6-methylprednisolone acetate). The results obtained were as follows. 1. The synovial concentration of lysozyme in patients with rheumatoid arthritis was found to be 10.88 mcg/ml which is higher than normal value of 8.69 mcg/ml. 2. The lysozyme activity of joint fluid obtained 5 days after intra-articular injection of steroid prepatation was variable ranging from 7.40 mcg/ml to 10.0mcg/ml with the average of 8.97 mcg/ml, which corresponded to the relief of clinical manifestations. 3. The lysozyme activity of joint fluid obtained 10 days after intra-articular injection of steroid preparation decreased to 8.36 mcg/ml on average with the range from 7.60 to 9.30 mcg/ml which was in accordance with much relief of clinical manifestations. 4. The lysozyme activity of joint fluid obtained 20 days after intra-articular steroid injection was 9.55 mcg/ml on average with the range from 8.25 to 11.25 mcg/ml which was in accordance with the aggravations of clinical manifestations.

MeSH Terms

Arthritis, Rheumatoid*
Humans
Injections, Intra-Articular*
Joints
Knee Joint
Muramidase*
Osteoarthritis
Reference Values
Muramidase