Ann Lab Med.  2020 Mar;40(2):187-189. 10.3343/alm.2020.40.2.187.

Red Blood Cell Alloimmunization in Pediatric Sickle Cell Disease Population of Puerto Rico: An Observational Study

• Balbuena-Merle RI
• Nazario-Delgado CM
• Rosario-Rosado RV
• Millán-Tapia D
• Climent-Peris C

• KMID: 2460920
• DOI: http://doi.org/10.3343/alm.2020.40.2.187

Abstract

No abstract available.

MeSH Terms

Anemia, Sickle Cell*
Erythrocytes*
Observational Study*
Puerto Rico*

Figure

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  Fig. 1 RBC alloantibody distribution and prevalence of new antibody formation in pediatric patients with SCD in Puerto Rico. (A) Number and antigen specificity of the nine alloantibodies formed by eight alloimmunized pediatric SCD patients. (B) Alloantibody formation following RBC transfusion based on degree of serologic RBC phenotype matching.Abbreviations: see Table 1.

Reference

1. Kim HY, Cho EJ, Chun S, Kim KH, Cho D. Red blood cell alloimmunization in Korean patients with myelodysplastic syndrome and liver cirrhosis. Ann Lab Med. 2019; 39:218–222. PMID: 30430787.

2. Chou ST, Jackson T, Vege S, Smith-Whitley K, Friedman DF, Westhoff CM. High prevalence of red blood cell alloimmunization in sickle cell disease despite transfusion from Rh-matched minority donors. Blood. 2013; 122:1062–1071. PMID: 23723452.

3. Yazdanbakhsh K, Ware RE, Noizat-Pirenne F. Red blood cell alloimmunization in sickle cell disease: pathophysiology, risk factors, and transfusion management. Blood. 2012; 120:528–537. PMID: 22563085.

4. Moreira Júnior G, Bordin JO, Kuroda A, Kerbauy J. Red blood cell alloimmunization in sickle cell disease: the influence of racial and antigenic pattern differences between donors and recipients in Brazil. Am J Hematol. 1996; 52:197–200. PMID: 8756087.

5. Samarah F, Srour MA, Yaseen D, Dumaidi K. Frequency of red blood cell alloimmunization in patients with sickle cell disease in Palestine. Adv Hematol. 2018; 2018:5356245. PMID: 29977298.

6. DeanL. Blood groups and red cell antigens. Bethesda: National Center for Biotechnology Information;2005. p. 32. p. 50. p. 57. p. 63. p. 69. p. 81.

7. Chou ST, Flanagan JM, Vege S, Luban NLC, Brown RC, Ware RE, et al. Whole-exome sequencing for RH genotyping and alloimmunization risk in children with sickle cell anemia. Blood Adv. 2017; 1:1414–1422. PMID: 29296782.

8. Chou ST, Evans P, Vege S, Coleman SL, Friedman DF, Keller M, et al. RH genotype matching for transfusion support in sickle cell disease. Blood. 2018; 132:1198–1207. PMID: 30026182.