Int J Oral Biol.  2019 Sep;44(3):71-76. 10.11620/IJOB.2019.44.3.71.

Update on dentin hypersensitivity: with the focus on hydrodynamic theory and mechanosensitive ion channels

  • 1Dental Research Institute and Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul 08826, Republic of Korea.
  • 2Department of Neurobiology & Physiology, School of Dentistry, Seoul National University, Seoul 03080, Republic of Korea.


Dentin hypersensitivity is an abrupt intense pain caused by innocuous stimuli to exposed dentinal tubules. Mechanosensitive ion channels have been assessed in dental primary afferent neurons and odontoblasts to explain dentin hypersensitivity. Dentinal fluid dynamics evoked by various stimuli to exposed dentin cause mechanical stress to the structures underlying dentin. This review briefly discusses three hypotheses regarding dentin hypersensitivity and introduces recent findings on mechanosensitive ion channels expressed in the dental sensory system and discusses how the activation of these ion channels is involved in dentin hypersensitivity.


Dentin hypersensitivity; Mechanoreceptor; Dental physiology; Hydrodynamic theory
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