Korean J Thorac Cardiovasc Surg.  2019 Oct;52(5):360-367. 10.5090/kjtcs.2019.52.5.360.

Primary Chest Wall Sarcoma: Surgical Outcomes and Prognostic Factors

• Park I
• Shin S
• Kim HK
• Choi YS
• Kim J
• Zo JI
• Shim YM
• Cho JH

• KMID: 2460470
• DOI: http://doi.org/10.5090/kjtcs.2019.52.5.360

Abstract

BACKGROUND
Primary chest wall sarcoma is a rare disease with limited reports of surgical resection.
METHODS
This retrospective review included 41 patients with primary chest wall sarcoma who underwent chest wall resection and reconstruction from 2001 to 2015. The clinical, histologic, and surgical variables were collected and analyzed by univariate and multivariate Cox regression analyses for overall survival (OS) and recurrence-free survival (RFS).
RESULTS
The OS rates at 5 and 10 years were 73% and 61%, respectively. The RFS rate at 10 years was 57.1%. Multivariate Cox regression analysis revealed old age (hazard ratio [HR], 5.16; 95% confidence interval [CI], 1.71-15.48) as a significant risk factor for death. A surgical resection margin distance of less than 1.5 cm (HR, 15.759; 95% CI, 1.78-139.46) and histologic grade III (HR, 28.36; 95% CI, 2.76-290.87) were independent risk factors for recurrence.
CONCLUSION
Long-term OS and RFS after the surgical resection of primary chest wall sarcoma were clinically acceptable.

Keyword

Sarcoma; Chest wall; Undifferentiated pleomorphic sarcoma

MeSH Terms

Humans
Rare Diseases
Recurrence
Retrospective Studies
Risk Factors
Sarcoma*
Thoracic Wall*
Thorax*